Role of miRNA Let-7 and Its Major Targets in Prostate Cancer

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dc.identifier.uri Wagner, Siegfried Ngezahayo, Anaclet Murua Escobar, Hugo Nolte, Ingo 2016-12-22T07:48:54Z 2016-12-22T07:48:54Z 2014
dc.identifier.citation Wagner, S.; Ngezahayo, A.; Murua, Escobar, H.; Nolte, I.: Role of miRNA Let-7 and Its Major Targets in Prostate Cancer. In: BioMed Research International 2014 (2014), 376326. DOI:
dc.description.abstract Prostate cancer is worldwide the sixth leading cause of cancer related death in men thus early detection and successful treatment are still of major interest. The commonly performed screening of the prostate-specific antigen (PSA) is controversially discussed, as in many patients the prostate-specific antigen levels are chronically elevated in the absence of cancer. Due to the unsatisfying efficiency of available prostate cancer screening markers and the current treatment outcome of the aggressive hormone refractory prostate cancer, the evaluation of novel molecular markers and targets is considered an issue of high importance. MicroRNAs are relatively stable in body fluids orchestrating simultaneously the expression of many genes. These molecules are currently discussed to bear a greater diagnostic potential than protein-coding genes, being additionally promising therapeutic drugs and/or targets. Herein we review the potential impact of the microRNA let-7 family on prostate cancer and show how deregulation of several of its target genes could influence the cellular equilibrium in the prostate gland, promoting cancer development as they do in a variety of other human malignant neoplasias. eng
dc.language.iso eng
dc.publisher London : BioMed Central Ltd.
dc.relation.ispartofseries BioMed Research International 2014 (2014)
dc.rights CC BY 3.0
dc.subject androgen receptor eng
dc.subject cyclin D2 eng
dc.subject glycogen synthase kinase 3 eng
dc.subject high mobility group A protein eng
dc.subject high mobility group A2 protein eng
dc.subject high mobility group B1 protein eng
dc.subject immunoglobulin enhancer binding protein eng
dc.subject interleukin 6 eng
dc.subject let 7 protein eng
dc.subject microRNA eng
dc.subject mitogen activated protein kinase eng
dc.subject Myc protein eng
dc.subject protein eng
dc.subject Ras protein eng
dc.subject unclassified drug eng
dc.subject deregulation eng
dc.subject gene targeting eng
dc.subject human eng
dc.subject nonhuman eng
dc.subject oncogene c myc eng
dc.subject prostate cancer eng
dc.subject biological model eng
dc.subject gene expression regulation eng
dc.subject genetics eng
dc.subject metabolism eng
dc.subject prostate tumor eng
dc.subject tumor gene eng
dc.subject Gene Expression Regulation, Neoplastic eng
dc.subject Male eng
dc.subject MicroRNAs eng
dc.subject Models, Biological eng
dc.subject Prostatic Neoplasms eng
dc.subject.ddc 610 | Medizin, Gesundheit ger
dc.title Role of miRNA Let-7 and Its Major Targets in Prostate Cancer
dc.type article
dc.type Text
dc.relation.issn 1110-7251
dc.bibliographicCitation.volume 2014
dc.bibliographicCitation.lastPage 376326
dc.description.version publishedVersion
tib.accessRights frei zug�nglich

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