Function of pathway specific regulators in the ACE1 and pyrichalasin H biosynthetic gene clusters

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dc.identifier.uri http://dx.doi.org/10.15488/9356
dc.identifier.uri https://www.repo.uni-hannover.de/handle/123456789/9410
dc.contributor.author Hantke, Verena ger
dc.contributor.author Wang, Chongqing ger
dc.contributor.author Skellam, Elizabeth J. ger
dc.contributor.author Cox, Russell J. ger
dc.date.accessioned 2020-02-14T11:22:59Z
dc.date.available 2020-02-14T11:22:59Z
dc.date.issued 2019
dc.identifier.citation Hantke, V.; Wang, C.; Skellam, E.J.; Cox, R.J.: Function of pathway specific regulators in the ACE1 and pyrichalasin H biosynthetic gene clusters. In: RSC Advances 61 (2019), 35797. DOI: https://doi.org/10.1039/c9ra07028a ger
dc.description.abstract Ectopic expression of BC1 which encodes a putative pathway specific transcription factor from the ACE1 biosynthetic gene cluster of the rice pathogen Pyricularia oryzae Guy11 did not lead to the production of ACE1-related compounds. However the known compound hinnulin A was formed. A putative partial gene cluster potentially involved in the biosynthesis of hinnulin A and DHN melanin was validated by RT-PCR and a possible biosynthetic pathway is proposed. Ectopic expression of pyiR which encodes a pathway specific transcription factor from the pyrichalasin H biosynthetic gene cluster in Magnaporthe grisea NI980 led to the apparent up-regulation of the pyi cluster and a 3-fold increase in pyrichalasin production under standard fermentation conditions, but did not lead to the formation of new compounds. ger
dc.language.iso eng ger
dc.publisher London : RSC
dc.relation.ispartofseries RSC Advances 61 (2019) ger
dc.rights CC BY-NC 3.0 Unported ger
dc.rights.uri https://creativecommons.org/licenses/by-nc/3.0/ ger
dc.subject ACE1 eng
dc.subject Pyricularia oryzae eng
dc.subject compounds eng
dc.subject.ddc 540 | Chemie ger
dc.title Function of pathway specific regulators in the ACE1 and pyrichalasin H biosynthetic gene clusters ger
dc.type article ger
dc.type Text ger
dc.relation.doi 10.1039/c9ra07028a
dc.description.version publishedVersion ger


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