Machine-assisted synthesis of modulators of the histone reader BRD9 using flow methods of chemistry and frontal affinity chromatography

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dc.identifier.uri http://dx.doi.org/10.15488/811
dc.identifier.uri http://www.repo.uni-hannover.de/handle/123456789/835
dc.contributor.author Guetzoyan, Lucie
dc.contributor.author Ingham, Richard J.
dc.contributor.author Nikbin, Nikzad
dc.contributor.author Rossignol, Julien
dc.contributor.author Wolling, Michael
dc.contributor.author Baumert, Mark
dc.contributor.author Burgess-Brown, Nicola A.
dc.contributor.author Strain-Damerell, Claire M.
dc.contributor.author Shrestha, Leela
dc.contributor.author Brennan, Paul E.
dc.contributor.author Fedorov, Oleg
dc.contributor.author Knapp, Stefan
dc.contributor.author Ley, Steven V.
dc.date.accessioned 2016-12-06T10:06:44Z
dc.date.available 2016-12-06T10:06:44Z
dc.date.issued 2014
dc.identifier.citation Guetzoyan, Lucie; Ingham, Richard J.; Nikbin, Nikzad; Rossignol, Julien; Wolling, Michael et al.: Machine-assisted synthesis of modulators of the histone reader BRD9 using flow methods of chemistry and frontal affinity chromatography. In: MedChemComm 5 (2014), Nr. 4, S. 540-546. DOI: http://dx.doi.org/10.1039/C4MD00007B
dc.description.abstract A combination of conventional organic synthesis, remotely monitored flow synthesis and bioassay platforms, were used for the evaluation of novel inhibitors targeting bromodomains outside the well-studied bromodomain and extra terminal (BET) family, here exemplified by activity measurements on the bromodomain of BRD9 protein, a component of some tissue-specific SWi/SNF chromatin remodelling complexes. The Frontal Affinity Chromatography combined with Mass Spectrometry (FAC-MS) method proved to be reliable and results correlated well with an independent thermal shift assay. eng
dc.description.sponsorship EPSRC/EP/F069685/1
dc.description.sponsorship Novartis
dc.description.sponsorship BP Endowment
dc.language.iso eng
dc.publisher Cambridge : Royal Society of Chemistry
dc.relation.ispartofseries MedChemComm 5 (2014), Nr. 4
dc.rights Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
dc.subject Biochemie eng
dc.subject FAC-MS eng
dc.subject Frontal Affinity Chromatography eng
dc.subject Mass Spectrometry eng
dc.subject.ddc 610 | Medizin, Gesundheit ger
dc.subject.ddc 570 | Biowissenschaften, Biologie ger
dc.title Machine-assisted synthesis of modulators of the histone reader BRD9 using flow methods of chemistry and frontal affinity chromatography
dc.type article
dc.type Text
dc.relation.essn 2040-2511
dc.relation.issn 2040-2503
dc.relation.doi http://dx.doi.org/10.1039/C4MD00007B
dc.bibliographicCitation.issue 4
dc.bibliographicCitation.volume 5
dc.bibliographicCitation.firstPage 540
dc.bibliographicCitation.lastPage 546
dc.description.version publishedVersion
tib.accessRights frei zug�nglich


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