Browsing Naturwissenschaftliche Fakultät by Author "0218ad9d-54e4-47f6-8dd2-16d0d500541c"

Browsing Naturwissenschaftliche Fakultät by Author "0218ad9d-54e4-47f6-8dd2-16d0d500541c"

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  • Diversely Functionalised Cytochalasins through Mutasynthesis and Semi-Synthesis 
    Wang, Chongqing; Lambert, Christopher; Hauser, Maurice; Deuschmann, Adrian; Zeilinger, Carsten; Rottner, Klemens; Stradal, Theresia E. B.; Stadler, Marc; Skellam, Elizabeth J.; Cox, Russell J. (Weinheim : Wiley-VCH, 2020)
    Mutasynthesis of pyrichalasin H from Magnaporthe grisea NI980 yielded a series of unprecedented 4′-substituted cytochalasin analogues in titres as high as the wild-type system (≈60 mg L−1). Halogenated, O-alkyl, O-allyl ...
  • Is Simultaneous Binding to DNA and Gyrase Important for the Antibacterial Activity of Cystobactamids? 
    Solga, Danny; Wieske, Lianne H. E.; Wilcox, Scott; Zeilinger, Carsten; Jansen‐Olliges, Linda; Cirnski, Katarina; Herrmann, Jennifer; Müller, Rolf; Erdelyi, Mate; Kirschning, Andreas (Weinheim : Wiley-VCH, 2024)
    Cystobactamids are aromatic oligoamides that exert their natural antibacterial properties by inhibition of bacterial gyrases. Such aromatic oligoamides were proposed to inhibit α-helix-mediated protein-protein interactions ...
  • Microarray-based screening system identifies temperature-controlled activity of Connexin 26 that is distorted by mutations 
    Wang, Hongling; Stahl, Frank; Scheper, Thomas; Steffens, Melanie; Warnecke, Athanasia; Zeilinger, Carsten (Berlin : Springer Nature, 2019)
    Here, we show that human Connexin 26 (hCx26 or Cx26WT) hemichannel opening rapidly enables the transport of small molecules when triggered by temperature and by compensation of the Ca2+ blockade with EDTA. Point mutations ...
  • MJK2, a K+Channel from M. Jannaschii Mediates pH Dependent Potassium Transport Activity 
    Zeilinger, Carsten (OMICS Pub. Group : Sunnyvale, Calif., 2014)
    MjK2 was expressed in E. coli cells as a fusion protein containing N-or C-terminal an antibody binding site and a histidinehexamer. The C-terminal tagged fusion protein allows the expression and purification of an extra ...
  • Multiformin-Type Azaphilones Prevent SARS-CoV-2 Binding to ACE2 Receptor 
    Jansen-Olliges, Linda; Chatterjee, Shambhabi; Jia, Lili; Stahl, Frank; Bär, Christian; Stadler, Marc; Surup, Frank; Zeilinger, Carsten (Basel : MDPI, 2023)
    Protein microarray screenings identified fungal natural products from the azaphilone family as potent inhibitors of SARS-CoV-2 spike protein binding to host ACE2 receptors. Cohaerin F, as the most potent substance from the ...
  • Multiplexed heat shock protein microarray as a screening platform for the selection of novel drug compounds 
    Schax, Emilia; Neunaber, Janek; Stahl, Frank; Walter, Johanna-Gabriela; Scheper, Thomas; Eichner, Simone; Kirschning, Andreas; Zeilinger, Carsten (Dundee : Dundee Science Press Ltd, 2014-12-22)
    In diseases such as cancer, Alzheimer’s disease or malaria, disease-related proteins take advantage of the heat shock protein (HSP) control system for their own activation or maturation. There is a quest to find inhibitors ...
  • New geldanamycin derivatives with anti Hsp properties by mutasynthesis 
    Hermane, Jekaterina; Eichner, Simone; Mancuso, Lena; Schröder, Benjamin; Sasse, Florenz; Zeilinger, Carsten; Kirschning, Andreas (Cambridge : Royal Society of Chemistry, 2019)
    Mutasynthetic supplementation of the AHBA blocked mutant strain of S. hygroscopicus, the geldanamycin producer, with 21 aromatic and heteroaromatic amino acids provided new nonquinoid geldanamycin derivatives. Large scale ...
  • New geldanamycin derivatives with anti Hsp properties by mutasynthesis 
    Hermane, Jekaterina; Eichner, Simone; Mancuso, Lena; Schröder, Benjamin; Sasse, Florenz; Zeilinger, Carsten; Kirschning, Andreas (Cambridge : Royal Society of Chemistry, 2019)
    Mutasynthetic supplementation of the AHBA blocked mutant strain of S. hygroscopicus, the geldanamycin producer, with 21 aromatic and heteroaromatic amino acids provided new nonquinoid geldanamycin derivatives. Large scale ...
  • pH-Dependent Conformational Changes of KcsA Tetramer and Monomer Probed by Raman Spectroscopy 
    Kniggendorf, Ann-Kathrin; Schmidt, David; Roth, Bernhard; Plettenburg, Oliver; Zeilinger, Carsten (Basel : MDPI AG, 2019)
    KcsA is a tetrameric potassium channel formed out of four identical monomeric subunits used as a standard model for selective potassium transport and pH-dependent gating. Large conformational changes are reported for ...
  • Targeting heat-shock-protein 90 (Hsp90) by natural products: Geldanamycin, a show case in cancer therapy 
    Franke, Jana; Eichner, Simone; Zeilinger, Carsten; Kirschning, Andreas (Cambridge : Royal Society of Chemistry, 2013)
    Covering: 2005 to 2013 In this review recent progress in the development of heat shock proteins (Hsp90) in oncogenesis is illuminated. Particular emphasis is put on inhibitors such as geldanamycin and analogues that serve ...
  • Triiodothyronine Acts as a Smart Influencer on Hsp90 via a Triiodothyronine Binding Site 
    Fan, Lu; Warnecke, Athanasia; Weder, Julia; Preller, Matthias; Zeilinger, Carsten (Basel : Molecular Diversity Preservation International (MDPI), 2022)
    Microarray-based experiments revealed that thyroid hormone triiodothyronine (T3) enhanced the binding of Cy5-labeled ATP on heat shock protein 90 (Hsp90). By molecular docking experiments with T3 on Hsp90, we identified a ...

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