The influence of storage and heat treatment on a magnesium-based implant material: An in vitro and in vivo study

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dc.identifier.uri Bracht, Katja Angrisani, Nina Seitz, Jan-Marten Eifler, Rainer Weizbauer, Andreas Reifenrath, Janin 2016-11-09T08:40:17Z 2016-11-09T08:40:17Z 2015
dc.identifier.citation Bracht, K.; Angrisani, N.; Seitz, J.-M.; Eifler, Rainer; Weizbauer, A. Et al.: The influence of storage and heat treatment on a magnesium-based implant material: An in vitro and in vivo study. In: BioMedical Engineering Online 14 (2015), Nr. 1 , 92. DOI:
dc.description.abstract Background: Magnesium alloys are recommended as a potential material for osteosynthesis. It is known that storage-induced property modifications can occur in materials like aluminum. Thus the aim of this study was to analyze the influence of storage durations of up to 48weeks on the biomechanical, structural, and degradation properties of the degradable magnesium alloy LAE442. Methods: Extruded implants (n=104; Ø 2.5mm×25mm) were investigated after storage periods of 0, 12, 24, and 48weeks in three different sub-studies: (I) immediately after the respective storage duration and after an additional (II) 56days of in vitro corrosion in simulated body fluid (SFB), and (III) 48weeks in vivo corrosion in a rabbit model, respectively. In addition, the influence of a T5-heat treatment (206°C for 15h in an argon atmosphere) was tested (n=26; 0week of storage). Evaluation was performed by three-point bending, scanning electron microscopy, radiography, μ-computed tomography, evaluation of the mean grain size, and contrast analysis of precipitations (such as aluminum or lithium). Results: The heat treatment induced a significant reduction in initial stability, and enhanced the corrosion resistance. In vivo experiments showed a good biocompatibility for all implants. During the storage of up to 48weeks, no significant changes occurred in the implant properties. Conclusions: LAE442 implants can be safely used after up to 48weeks of storage. eng
dc.description.sponsorship DFG/SFB/599
dc.language.iso eng
dc.publisher London : BioMed Central Ltd.
dc.relation.ispartofseries BioMedical Engineering Online 14 (2015), Nr. 1
dc.rights CC BY 4.0
dc.subject Degradable eng
dc.subject Aluminum eng
dc.subject In vitro eng
dc.subject In vivo eng
dc.subject Magnesium eng
dc.subject Storage eng
dc.subject Biocompatibility eng
dc.subject Computerized tomography eng
dc.subject Corrosion eng
dc.subject Corrosion resistance eng
dc.subject Energy storage eng
dc.subject Heat resistance eng
dc.subject Heat treatment eng
dc.subject Magnesium alloys eng
dc.subject Scanning electron microscopy eng
dc.subject Degradable eng
dc.subject In-vitro corrosions eng
dc.subject In-vivo experiments eng
dc.subject Initial stabilities eng
dc.subject Simulated body fluids eng
dc.subject body fluid eng
dc.subject Three point bending eng
dc.subject Storage (materials) eng
dc.subject alloy eng
dc.subject lithium eng
dc.subject unclassified drug eng
dc.subject animal experiment eng
dc.subject animal model eng
dc.subject biocompatibility eng
dc.subject biomechanics eng
dc.subject bone mass eng
dc.subject controlled study eng
dc.subject corrosion eng
dc.subject degradation eng
dc.subject energy dispersive spectroscopy eng
dc.subject evaluation study eng
dc.subject ex vivo study eng
dc.subject experimental design eng
dc.subject grain eng
dc.subject heat treatment eng
dc.subject implant eng
dc.subject in vitro study eng
dc.subject in vivo study eng
dc.subject micro-computed tomography eng
dc.subject nonhuman eng
dc.subject precipitation eng
dc.subject priority journal eng
dc.subject rabbit model eng
dc.subject radiography eng
dc.subject scanning electron microscopy eng
dc.subject spectroscopy eng
dc.subject three point bending eng
dc.subject.ddc 600 | Technik ger
dc.subject.ddc 610 | Medizin, Gesundheit ger
dc.subject.ddc 570 | Biowissenschaften, Biologie ger
dc.title The influence of storage and heat treatment on a magnesium-based implant material: An in vitro and in vivo study
dc.type article
dc.type Text
dc.relation.issn 1475-925X
dc.bibliographicCitation.issue 1
dc.bibliographicCitation.volume 14
dc.bibliographicCitation.firstPage 92
dc.description.version publishedVersion
tib.accessRights frei zug�nglich

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