Preliminary results in anterior cervical discectomy and fusion with an experimental bioabsorbable cage - clinical and radiological findings in an ovine animal model

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dc.identifier.uri http://dx.doi.org/10.15488/644
dc.identifier.uri http://www.repo.uni-hannover.de/handle/123456789/668
dc.contributor.author Daentzer, Dorothea
dc.contributor.author Floerkemeier, Thilo
dc.contributor.author Bartsch, Ivonne
dc.contributor.author Masalha, Waseem
dc.contributor.author Welke, Bastian
dc.contributor.author Hurschler, Christof
dc.contributor.author Kauth, Theresa
dc.contributor.author Kaltbeitzel, Daniel
dc.contributor.author Hopmann, Christian
dc.contributor.author Kujat, Bernd
dc.contributor.author Kalla, Katharina
dc.date.accessioned 2016-11-03T12:40:16Z
dc.date.available 2016-11-03T12:40:16Z
dc.date.issued 2013
dc.identifier.citation Daentzer, D.; Floerkemeier, T.; Bartsch, I.; Masalha, W.; Welke, B. et al.: Preliminary results in anterior cervical discectomy and fusion with an experimental bioabsorbable cage - clinical and radiological findings in an ovine animal model. In: SpringerPlus 2 (2013), Nr. 1 , S. 1-8. DOI: http://dx.doi.org/10.1186/2193-1801-2-418
dc.description.abstract Background: Bioabsorbable implants are not widely used in spine surgery. This study investigated the clinical and radiological findings after anterior cervical discectomy and fusion (ACDF) in an ovine animal model with an experimental bioabsorbable cage consisting of magnesium and polymer (poly-ε-caprolactone, PCL) in comparison to a tricortical bone graft as the gold standard procedure. Materials and Methods: 24 full-grown sheep had ACDF of C3/4 and C5/6 with an experimental bioabsorbable implant (magnesium and PCL) in one level and an autologous tricortical bone graft in the second level. The sheep were divided into 4 groups (6 sheep each). After 3, 6, 12, or 24 weeks postoperatively, the cervical spines were harvested and conventional x-rays of each operated segment were conducted. The progress of interbody fusion was classified according to a three-point scoring system. Results: There were no operation related complications except for one intraoperative fracture of the anterior superior iliac spine and two cases of screw loosening and sinking, respectively. In particular, no vascular, neurologic, wound healing or infectious problems were observed. According to the time of follow-up, both interbody fusion devices showed similar behaviour with increasing intervertebral osseointegration and complete arthrodesis in 10 of 12 (83.3%) motion segments after 24 weeks. Conclusions: The bioabsorbable magnesium-PCL cage used in this experimental animal study showed clinically no signs of incompatibility such as infectious or wound healing problems. The radiographic results regarding the osseointegration are comparable between the cage and the bone graft group. eng
dc.description.sponsorship Arbeitsgemeinschaft industrieller Forschungsvereinigungen (AiF)
dc.description.sponsorship German Federal Ministry of Economy and Technology (BMWi)
dc.language.iso eng
dc.publisher Heidelberg : SpringerOpen
dc.relation.ispartofseries SpringerPlus 2 (2013), Nr. 1
dc.rights CC BY 2.0
dc.rights.uri https://creativecommons.org/licenses/by/2.0/
dc.subject ACDF eng
dc.subject Animal model eng
dc.subject Bioabsorbable cage eng
dc.subject Cervical spine eng
dc.subject Fusion eng
dc.subject Magnesium eng
dc.subject Ovine animal model eng
dc.subject Poly-ε-caprolactone eng
dc.subject Polymer eng
dc.subject Sheep eng
dc.subject.ddc 500 | Naturwissenschaften ger
dc.title Preliminary results in anterior cervical discectomy and fusion with an experimental bioabsorbable cage - clinical and radiological findings in an ovine animal model
dc.type article
dc.type Text
dc.relation.issn 2193-1801
dc.relation.doi http://dx.doi.org/10.1186/2193-1801-2-418
dc.bibliographicCitation.issue 1
dc.bibliographicCitation.volume 2
dc.bibliographicCitation.firstPage 1
dc.bibliographicCitation.lastPage 8
dc.description.version publishedVersion
tib.accessRights frei zug�nglich


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