dc.identifier.uri |
http://dx.doi.org/10.15488/5352 |
|
dc.identifier.uri |
https://www.repo.uni-hannover.de/handle/123456789/5399 |
|
dc.contributor.author |
Kuhn, Antonia I.
|
|
dc.contributor.author |
Müller, Marc
|
|
dc.contributor.author |
Knigge, Sara
|
|
dc.contributor.author |
Glasmacher, Birgit
|
|
dc.date.accessioned |
2019-09-03T12:13:08Z |
|
dc.date.available |
2019-09-03T12:13:08Z |
|
dc.date.issued |
2016 |
|
dc.identifier.citation |
Kuhn, A.I.; Müller, M.; Knigge, S.; Glasmacher, B.: Novel blood protein based scaffolds for cardiovascular tissue engineering. In: Current Directions in Biomedical Engineering 2 (2016), Nr. 1, S. 5-9. DOI: https://doi.org/10.1515/cdbme-2016-0005 |
|
dc.description.abstract |
A major challenge in cardiovascular tissue engineering is the fabrication of scaffolds, which provide appropriate morphological and mechanical properties while avoiding undesirable immune reactions. In this study electrospinning was used to fabricate scaffolds out of blood proteins for cardiovascular tissue engineering. Lyophilised porcine plasma was dissolved in deionised water at a final concentration of 7.5% m/v and blended with 3.7% m/v PEO. Electrospinning resulted in homogeneous fibre morphologies with a mean fibre diameter of 151 nm, which could be adapted to create macroscopic shapes (mats, tubes). Cross-linking with glutaraldehyde vapour improved the long-term stability of protein based scaffolds in comparison to untreated scaffolds, resulting in a mass loss of 41% and 96% after 28 days of incubation in aqueous solution, respectively. |
eng |
dc.language.iso |
eng |
|
dc.publisher |
Berlin : Walter de Gruyter |
|
dc.relation.ispartofseries |
Current Directions in Biomedical Engineering 2 (2016), Nr. 1 |
|
dc.rights |
CC BY-NC-ND 4.0 Unported |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
|
dc.subject |
Biopolymer solution |
eng |
dc.subject |
Biostability analysis |
eng |
dc.subject |
Blood protein based scaffold |
eng |
dc.subject |
Cross-linking |
eng |
dc.subject |
Electrospinning |
eng |
dc.subject |
Glutaraldehyde vapour |
eng |
dc.subject |
Long-term stability |
eng |
dc.subject |
Tissue engineering |
eng |
dc.subject.ddc |
570 | Biowissenschaften, Biologie
|
ger |
dc.title |
Novel blood protein based scaffolds for cardiovascular tissue engineering |
eng |
dc.type |
Article |
|
dc.type |
Text |
|
dc.relation.issn |
2364-5504 |
|
dc.relation.doi |
https://doi.org/10.1515/cdbme-2016-0005 |
|
dc.bibliographicCitation.issue |
1 |
|
dc.bibliographicCitation.volume |
2 |
|
dc.bibliographicCitation.firstPage |
5 |
|
dc.bibliographicCitation.lastPage |
9 |
|
dc.description.version |
publishedVersion |
|
tib.accessRights |
frei zug�nglich |
|