Concentric and eccentric endurance exercise reverse hallmarks of T-Cell senescence in pre-diabetic subjects

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dc.identifier.uri http://dx.doi.org/10.15488/5222
dc.identifier.uri https://www.repo.uni-hannover.de/handle/123456789/5269
dc.contributor.author Philippe, Marc
dc.contributor.author Gatterer, Hannes
dc.contributor.author Burtscher, Martin
dc.contributor.author Weinberger, Birgit
dc.contributor.author Keller, Michael
dc.contributor.author Grubeck-Loebenstein, Beatrix
dc.contributor.author Fleckenstein, Johannes
dc.contributor.author Alack, Katharina
dc.contributor.author Krüger, Karsten
dc.date.accessioned 2019-08-26T07:56:07Z
dc.date.available 2019-08-26T07:56:07Z
dc.date.issued 2019
dc.identifier.citation Philippe, M.; Gatterer, H.; Burtscher, M.; Weinberger, B.; Keller, M. et al.: Concentric and eccentric endurance exercise reverse hallmarks of T-Cell senescence in pre-diabetic subjects. In: Frontiers in Physiology 10 (2019), 684. DOI: https://doi.org/10.3389/fphys.2019.00684
dc.description.abstract The peripheral T-cell pool undergoes a striking age associated remodeling which is accelerated by progressive insulin resistance. Exercise training is known to delay several aspects of T-cell senescence. The purpose of the current study was to investigate the effect of 3 weeks regular concentric or eccentric endurance exercise training on the composition of the T-cell compartment in pre-diabetic subjects. Sixteen male older adults with impaired glucose tolerance were recruited and performed either concentric exercise (CE) or eccentric exercise (EE) walking 3 times a week for 3 weeks. Fasting venous blood sampling was performed before training and after the training intervention. Various T-cell subpopulations were analyzed by flow cytometry. We did not find significant time × group effects (interaction) but found several significant time effects for cell type ratios and cell subsets proportions. There was an increase of the CD4+/CD8+ (0.55 ± 0.85%; p = 0.033) and CD4+/CD3+ ratio (5.63 ± 8.44%; p = 0.018) and a decrease of the CD8+/CD3+ ratio (-0.95 ± 1.64%; p = 0.049) after training. We found proportional increases of CD4+/CCR7+/CD45RO+ central memory cells (5.02 ± 7.68%; p = 0.030), naïve CD8+/CCR7+/CD45RO- (3.00 ± 6.68%; p = 0.047) and CD8+/CCR7+/CD45RO+ central memory cells (3.01 ± 3.70%; p = 0.009), while proportions of CD4+/CCR7-/CD45RO- TEMRA cells (-2.17 ± 4.66%; p = 0.012), CD8+/CCR7-/CD45RO- TEMRA cells (-5.11 ± 7.02%; p = 0.018) and CD16+ cells (-4.67 ± 6.45%; p = 0.016) decreased after training. 3 weeks of either CE or EE were effective in reversing hallmarks of T-cell senescence in pre-diabetic subjects. It is suggested that exercise stimulates production and mobilization of naïve T-cells, while differentiated TEMRA cells might disappear by apoptosis. eng
dc.language.iso eng
dc.publisher Lausanne : Frontiers Media S.A.
dc.relation.ispartofseries Frontiers in Physiology 10 (2019)
dc.rights CC BY 4.0
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject Concentric exercise eng
dc.subject Eccentric exercise eng
dc.subject Inflammation eng
dc.subject Naïve T-cells eng
dc.subject TEMRA cells eng
dc.subject.ddc 510 | Mathematik ger
dc.title Concentric and eccentric endurance exercise reverse hallmarks of T-Cell senescence in pre-diabetic subjects
dc.type article
dc.type Text
dc.relation.issn 1664-042X
dc.relation.doi https://doi.org/10.3389/fphys.2019.00684
dc.bibliographicCitation.volume 10
dc.bibliographicCitation.firstPage 684
dc.description.version publishedVersion
tib.accessRights frei zug�nglich


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