dc.identifier.uri |
http://dx.doi.org/10.15488/5222 |
|
dc.identifier.uri |
https://www.repo.uni-hannover.de/handle/123456789/5269 |
|
dc.contributor.author |
Philippe, Marc
|
|
dc.contributor.author |
Gatterer, Hannes
|
|
dc.contributor.author |
Burtscher, Martin
|
|
dc.contributor.author |
Weinberger, Birgit
|
|
dc.contributor.author |
Keller, Michael
|
|
dc.contributor.author |
Grubeck-Loebenstein, Beatrix
|
|
dc.contributor.author |
Fleckenstein, Johannes
|
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dc.contributor.author |
Alack, Katharina
|
|
dc.contributor.author |
Krüger, Karsten
|
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dc.date.accessioned |
2019-08-26T07:56:07Z |
|
dc.date.available |
2019-08-26T07:56:07Z |
|
dc.date.issued |
2019 |
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dc.identifier.citation |
Philippe, M.; Gatterer, H.; Burtscher, M.; Weinberger, B.; Keller, M. et al.: Concentric and eccentric endurance exercise reverse hallmarks of T-Cell senescence in pre-diabetic subjects. In: Frontiers in Physiology 10 (2019), 684. DOI: https://doi.org/10.3389/fphys.2019.00684 |
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dc.description.abstract |
The peripheral T-cell pool undergoes a striking age associated remodeling which is accelerated by progressive insulin resistance. Exercise training is known to delay several aspects of T-cell senescence. The purpose of the current study was to investigate the effect of 3 weeks regular concentric or eccentric endurance exercise training on the composition of the T-cell compartment in pre-diabetic subjects. Sixteen male older adults with impaired glucose tolerance were recruited and performed either concentric exercise (CE) or eccentric exercise (EE) walking 3 times a week for 3 weeks. Fasting venous blood sampling was performed before training and after the training intervention. Various T-cell subpopulations were analyzed by flow cytometry. We did not find significant time × group effects (interaction) but found several significant time effects for cell type ratios and cell subsets proportions. There was an increase of the CD4+/CD8+ (0.55 ± 0.85%; p = 0.033) and CD4+/CD3+ ratio (5.63 ± 8.44%; p = 0.018) and a decrease of the CD8+/CD3+ ratio (-0.95 ± 1.64%; p = 0.049) after training. We found proportional increases of CD4+/CCR7+/CD45RO+ central memory cells (5.02 ± 7.68%; p = 0.030), naïve CD8+/CCR7+/CD45RO- (3.00 ± 6.68%; p = 0.047) and CD8+/CCR7+/CD45RO+ central memory cells (3.01 ± 3.70%; p = 0.009), while proportions of CD4+/CCR7-/CD45RO- TEMRA cells (-2.17 ± 4.66%; p = 0.012), CD8+/CCR7-/CD45RO- TEMRA cells (-5.11 ± 7.02%; p = 0.018) and CD16+ cells (-4.67 ± 6.45%; p = 0.016) decreased after training. 3 weeks of either CE or EE were effective in reversing hallmarks of T-cell senescence in pre-diabetic subjects. It is suggested that exercise stimulates production and mobilization of naïve T-cells, while differentiated TEMRA cells might disappear by apoptosis. |
eng |
dc.language.iso |
eng |
|
dc.publisher |
Lausanne : Frontiers Media S.A. |
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dc.relation.ispartofseries |
Frontiers in Physiology 10 (2019) |
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dc.rights |
CC BY 4.0 Unported |
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dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
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dc.subject |
Concentric exercise |
eng |
dc.subject |
Eccentric exercise |
eng |
dc.subject |
Inflammation |
eng |
dc.subject |
Naïve T-cells |
eng |
dc.subject |
TEMRA cells |
eng |
dc.subject.ddc |
510 | Mathematik
|
ger |
dc.title |
Concentric and eccentric endurance exercise reverse hallmarks of T-Cell senescence in pre-diabetic subjects |
eng |
dc.type |
Article |
|
dc.type |
Text |
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dc.relation.issn |
1664-042X |
|
dc.relation.doi |
https://doi.org/10.3389/fphys.2019.00684 |
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dc.bibliographicCitation.volume |
10 |
|
dc.bibliographicCitation.firstPage |
684 |
|
dc.description.version |
publishedVersion |
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tib.accessRights |
frei zug�nglich |
|