TFG Promotes Organization of Transitional ER and Efficient Collagen Secretion

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dc.identifier.uri McCaughey, Janine Miller, Victoria J. Stevenson, Nicola L. Brown, Anna K. Budnik, Annika Heesom, Kate J. Alibhai, Dominic Stephens, David J. 2016-09-02T08:00:21Z 2016-09-02T08:00:21Z 2016
dc.identifier.citation McCaughey, Janine; Miller, Victoria J.; Stevenson, Nicola L.; Brown, Anna K.; Budnik, Annika et al.: TFG Promotes Organization of Transitional ER and Efficient Collagen Secretion. In: Cell Reports 15 (2016), Nr. 8, S. 1648-1659. DOI:
dc.description.abstract Collagen is the most abundant protein in the animal kingdom. It is of fundamental importance during development for cell differentiation and tissue morphogenesis as well as in pathological processes such as fibrosis and cancer cell migration. However, our understanding of the mechanisms of procollagen secretion remains limited. Here, we show that TFG organizes transitional ER (tER) and ER exit sites (ERESs) into larger structures. Depletion of TFG results in dispersion of tER elements that remain associated with individual ER-Golgi intermediate compartments (ERGICs) as largely functional ERESs. We show that TFG is not required for the transport and packaging of small soluble cargoes but is necessary for the export of procollagen from the ER. Our work therefore suggests a key relationship between the structure and function of ERESs and a central role for TFG in optimizing COPII assembly for procollagen export. eng
dc.description.sponsorship Medical Research Council UK/MR/J000604/1
dc.description.sponsorship Medical Research Council UK/MR/K018019/1
dc.description.sponsorship Medical Research Council UK/MR/G0801848
dc.language.iso eng
dc.publisher Amsterdam : Elsevier
dc.relation.ispartofseries Cell Reports 15 (2016), Nr. 8
dc.rights CC BY 4.0 Unported
dc.subject TFG eng
dc.subject collagen eng
dc.subject ERESs eng
dc.subject.ddc 570 | Biowissenschaften, Biologie ger
dc.title TFG Promotes Organization of Transitional ER and Efficient Collagen Secretion eng
dc.type article
dc.type Text
dc.relation.issn 2211-1247
dc.bibliographicCitation.issue 8
dc.bibliographicCitation.volume 15
dc.bibliographicCitation.firstPage 1648
dc.bibliographicCitation.lastPage 1659
dc.description.version publishedVersion
tib.accessRights frei zug�nglich

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