Comparison of two prototypes of a magnetically adjustable glaucoma implant in rabbits

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dc.identifier.uri Schwerk, Birthe Harder, Lisa Windhövel, Claudia Hewicker-Trautwein, Marion Wagner, Anna Bach, Jan-Peter Voigt, Lena Carolin Hinze, Ulf Chichkov, Boris Haferkamp, Heinz Lubatschowski, Holger Nikolic, Stephan Nolte, Ingo 2019-07-02T07:58:23Z 2019-07-02T07:58:23Z 2019
dc.identifier.citation Schwerk, B.; Harder, L.; Windhövel, C.; Hewicker-Trautwein, M.; Wagner, A. et al.: Comparison of two prototypes of a magnetically adjustable glaucoma implant in rabbits. In: PLoS ONE 14 (2019), Nr. 4, e0215316. DOI:
dc.description.abstract Glaucoma drainage devices are used in surgical glaucoma therapy. Success of controlling the intraocular pressure is limited due to fibrous implant encapsulation and fibrin coating on the implant which lead to drainage obstructions. An innovative implant with a magnetically adjustable valve was developed. The valve opening of the implant should eliminate inflammatory products from the outflow area and affect fibrous tissue formation to achieve a sufficient long-term aqueous humour outflow. Lifting of this valve should disturb cell adhesion by exerting mechanical forces. Before testing this hypothesis, the flow characteristics of glaucoma drainage devices, especially the outflow resistance by regular IOP, should be considered in a pilot study, as they are important in preventing too low postoperative intraocular pressure known as ocular hypotony. Therefore, two prototypes of the innovative implant differing in their valve area design were examined regarding their flow characteristics in a limited animal experiment lasting two weeks. Ten healthy New Zealand White rabbits were divided into two groups (A & B) with different implanted prototypes. Daily, tonometry and direct ophthalmoscopy were performed to assess the intraocular pressure and the inflammatory reaction of the eye. After two weeks, the rabbits were euthanised to evaluate the initially histological inflammatory reaction to the implant. In group A, one case of hypotony emerged. When considering the entire observation period, a highly statistically significant difference between the intraocular pressure in the operated eye and that in the control eye was detected in group A (p < 0.0001) in contrast to group B (p = 0.0063). The postoperative inflammatory signs decreased within two weeks. Histologically, a typical but low level foreign body reaction with macrophages and lymphocytes as well as mild to moderate fibrosis was seen after the short experimental period. Based on our tonometric results, prototype B seems to be the system of choice for further research assessing its long-term function and biocompatibility. eng
dc.language.iso eng
dc.publisher San Francisco, CA : Public Library of Science (PLoS)
dc.relation.ispartofseries PLoS ONE 14 (2019), Nr. 4
dc.rights CC BY 4.0 Unported
dc.subject dexamethasone eng
dc.subject meloxicam eng
dc.subject neomycin eng
dc.subject polymyxin eng
dc.subject animal cell eng
dc.subject animal experiment eng
dc.subject animal model eng
dc.subject Article eng
dc.subject biocompatibility eng
dc.subject blepharospasm eng
dc.subject controlled study eng
dc.subject disease severity eng
dc.subject erythema eng
dc.subject eye inflammation eng
dc.subject eye swelling eng
dc.subject female eng
dc.subject foreign body reaction eng
dc.subject geometry eng
dc.subject histology eng
dc.subject hyperemia eng
dc.subject implantation eng
dc.subject in vivo study eng
dc.subject intraocular hemorrhage eng
dc.subject intraocular hypotension eng
dc.subject intraocular pressure eng
dc.subject iris disease eng
dc.subject iris hyperemia eng
dc.subject Leporidae eng
dc.subject lymphocyte eng
dc.subject macrophage eng
dc.subject magnetically adjustable glaucoma implant eng
dc.subject New Zealand White (rabbit) eng
dc.subject nonhuman eng
dc.subject ocular fibrosis eng
dc.subject operation duration eng
dc.subject ophthalmoscopy eng
dc.subject pilot study eng
dc.subject slit lamp microscopy eng
dc.subject thickness eng
dc.subject tonometry eng
dc.subject.ddc 500 | Naturwissenschaften ger
dc.subject.ddc 610 | Medizin, Gesundheit ger
dc.title Comparison of two prototypes of a magnetically adjustable glaucoma implant in rabbits eng
dc.type Article
dc.type Text
dc.relation.issn 1932-6203
dc.bibliographicCitation.issue 4
dc.bibliographicCitation.volume 14
dc.bibliographicCitation.firstPage e0215316
dc.description.version publishedVersion
tib.accessRights frei zug�nglich

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