Cardiac T2-mapping using a fast gradient echo spin echo sequence - first in vitro and in vivo experience

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dc.identifier.uri Baessler, Bettina Schaarschmidt, Frank Stehning, Christian Schnackenburg, Bernhard Maintz, David Bunck, Alexander C. 2016-08-29T08:04:57Z 2016-08-29T08:04:57Z 2015-08-01
dc.identifier.citation Baessler, Bettina; Schaarschmidt, Frank; Stehning, Christian; Schnackenburg, Bernhard; Maintz, David; Bunck, Alexander C.: Cardiac T2-mapping using a fast gradient echo spin echo sequence - first in vitro and in vivo experience. In: Journal of Cardiovascular Magnetic Resonance 17 (2015), 67. DOI:
dc.description.abstract Background: The aim of this study was the evaluation of a fast Gradient Spin Echo Technique (GraSE) for cardiac T2-mapping, combining a robust estimation of T2 relaxation times with short acquisition times. The sequence was compared against two previously introduced T2-mapping techniques in a phantom and in vivo. Methods: Phantom experiments were performed at 1.5 T using a commercially available cylindrical gel phantom. Three different T2-mapping techniques were compared: a Multi Echo Spin Echo (MESE; serving as a reference), a T2-prepared balanced Steady State Free Precession (T2prep) and a Gradient Spin Echo sequence. For the subsequent in vivo study, 12 healthy volunteers were examined on a clinical 1.5 T scanner. The three T2-mapping sequences were performed at three short-axis slices. Global myocardial T2 relaxation times were calculated and statistical analysis was performed. For assessment of pixel-by-pixel homogeneity, the number of segments showing an inhomogeneous T2 value distribution, as defined by a pixel SD exceeding 20 % of the corresponding observed T2 time, was counted. Results: Phantom experiments showed a greater difference of measured T2 values between T2prep and MESE than between GraSE and MESE, especially for species with low T1 values. Both, GraSE and T2prep resulted in an overestimation of T2 times compared to MESE. In vivo, significant differences between mean T2 times were observed. In general, T2prep resulted in lowest (52.4 +/- 2.8 ms) and GraSE in highest T2 estimates (59.3 +/- 4.0 ms). Analysis of pixel-by-pixel homogeneity revealed the least number of segments with inhomogeneous T2 distribution for GraSE-derived T2 maps. Conclusions: The GraSE sequence is a fast and robust sequence, combining advantages of both MESE and T2prep techniques, which promises to enable improved clinical applicability of T2-mapping in the future. Our study revealed significant differences of derived mean T2 values when applying different sequence designs. Therefore, a systematic comparison of different cardiac T2-mapping sequences and the establishment of dedicated reference values should be the goal of future studies. eng
dc.language.iso eng
dc.publisher London : Biomed Central Ltd.
dc.relation.ispartofseries Journal of Cardiovascular Magnetic Resonance 17 (2015)
dc.rights CC BY 4.0 Unported
dc.subject cardiovascular magnetic resonance eng
dc.subject t2-mapping eng
dc.subject parametric imaging eng
dc.subject cardiovascular magnetic-resonance eng
dc.subject acute myocardial-infarction eng
dc.subject t2 eng
dc.subject edema eng
dc.subject heart eng
dc.subject risk eng
dc.subject area eng
dc.subject.ddc 500 | Naturwissenschaften ger
dc.title Cardiac T2-mapping using a fast gradient echo spin echo sequence - first in vitro and in vivo experience eng
dc.type Article
dc.type Text
dc.relation.essn 1532-429X
dc.relation.issn 1097-6647
dc.bibliographicCitation.volume 17
dc.bibliographicCitation.firstPage 67
dc.description.version publishedVersion
tib.accessRights frei zug�nglich

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