Characterisation of the biosynthetic pathway to agnestins A and B reveals the reductive route to chrysophanol in fungi

Szwalbe, Agniezka J.; Williams, Katherine; Song, Zhongshu; De Mattos-Shipley, Kate M.J.; Vincent, Jason L.; Bailey, Andrew M.; Willis, Christine L.; Cox, Russell J.; Simpson, Thomas J.

dc.identifier.uri	http://dx.doi.org/10.15488/4291
dc.identifier.uri	https://www.repo.uni-hannover.de/handle/123456789/4325
dc.contributor.author	Szwalbe, Agniezka J.
dc.contributor.author	Williams, Katherine
dc.contributor.author	Song, Zhongshu
dc.contributor.author	De Mattos-Shipley, Kate M.J.
dc.contributor.author	Vincent, Jason L.
dc.contributor.author	Bailey, Andrew M.
dc.contributor.author	Willis, Christine L.
dc.contributor.author	Cox, Russell J.
dc.contributor.author	Simpson, Thomas J.
dc.date.accessioned	2019-01-11T08:57:40Z
dc.date.available	2019-01-11T08:57:40Z
dc.date.issued	2019
dc.identifier.citation	Szwalbe, A.J.; Williams, K.; Song, Z.; De Mattos-Shipley, K.; Vincent, J. et al.: Characterisation of the biosynthetic pathway to agnestins A and B reveals the reductive route to chrysophanol in fungi. In: Chemical Science 10 (2019), Nr. 1, S. 233-238. DOI: https://doi.org/10.1039/C8SC03778G
dc.description.abstract	Two new dihydroxy-xanthone metabolites, agnestins A and B, were isolated from Paecilomyces variotii along with a number of related benzophenones and xanthones including monodictyphenone. The structures were elucidated by NMR analyses and X-ray crystallography. The agnestin (agn) biosynthetic gene cluster was identified and targeted gene disruptions of the PKS, Baeyer-Villiger monooxygenase, and other oxido-reductase genes revealed new details of fungal xanthone biosynthesis. In particular, identification of a reductase responsible for in vivo anthraquinone to anthrol conversion confirms a previously postulated essential step in aromatic deoxygenation of anthraquinones, e.g. emodin to chrysophanol.	eng
dc.language.iso	eng
dc.publisher	Cambridge : Royal Society of Chemistry
dc.relation.ispartofseries	Chemical Science 10 (2019), Nr. 1
dc.rights	CC BY 3.0 Unported
dc.rights.uri	https://creativecommons.org/licenses/by/3.0/
dc.subject	Aromatic compounds	eng
dc.subject	Biochemistry	eng
dc.subject	Biosynthesis	eng
dc.subject	Genes	eng
dc.subject	Ketones	eng
dc.subject	Baeyer-Villiger monooxygenases	eng
dc.subject	Biosynthetic gene cluster	eng
dc.subject	Biosynthetic pathway	eng
dc.subject	Deoxygenations	eng
dc.subject	Gene disruptions	eng
dc.subject	NMR analysis	eng
dc.subject	Oxido-reductases	eng
dc.subject	Paecilomyces variotii	eng
dc.subject	X ray crystallography	eng
dc.subject.ddc	540 \| Chemie	ger
dc.title	Characterisation of the biosynthetic pathway to agnestins A and B reveals the reductive route to chrysophanol in fungi	eng
dc.type	Article
dc.type	Text
dc.relation.issn	2041-6520
dc.relation.doi	https://doi.org/10.1039/C8SC03778G
dc.bibliographicCitation.issue	1
dc.bibliographicCitation.volume	10
dc.bibliographicCitation.firstPage	233
dc.bibliographicCitation.lastPage	238
dc.description.version	publishedVersion
tib.accessRights	frei zug�nglich