dc.identifier.uri |
http://dx.doi.org/10.15488/3893 |
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dc.identifier.uri |
https://www.repo.uni-hannover.de/handle/123456789/3927 |
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dc.contributor.author |
Pilz, Stefan
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dc.contributor.author |
Zittermann, Armin
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dc.contributor.author |
Obeid, Rima
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dc.contributor.author |
Hahn, Andreas
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dc.contributor.author |
Pludowski, Pawel
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dc.contributor.author |
Trummer, Christian
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dc.contributor.author |
Lerchbaum, Elisabeth
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dc.contributor.author |
Pérez-López, Faustino R.
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dc.contributor.author |
Karras, Spyridon N.
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dc.contributor.author |
März, Winfried
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dc.date.accessioned |
2018-10-26T13:41:52Z |
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dc.date.available |
2018-10-26T13:41:52Z |
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dc.date.issued |
2018 |
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dc.identifier.citation |
Pilz, S. et al.: The Role of Vitamin D in Fertility and during Pregnancy and Lactation: A Review of Clinical Data. In: International Journal of Environmental Research and Public Health 15 (2018), 2241. DOI: https://doi.org/10.3390/ijerph15102241 |
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dc.description.abstract |
Vitamin D deficiency is common and there exists a huge gap between recommended dietary vitamin D intakes and the poor vitamin D supply in the general population. While vitamin D is important for musculoskeletal health, there are accumulating data suggesting that vitamin D may also be important for fertility, pregnancy outcomes and lactation. Significant changes in vitamin D metabolism during pregnancy such as increased production of the “active vitamin D hormone” calcitriol support the important role of vitamin D in this setting. Observational studies show that vitamin D deficiency is a risk marker for reduced fertility and various adverse pregnancy outcomes and is associated with a low vitamin D content of breast milk. Meta-analyses of randomized controlled trials (RCTs) document that physiological vitamin D supplementation during pregnancy is safe and improves vitamin D and calcium status, thereby protecting skeletal health. Although certain RCTs and/or meta-analyses reported some other beneficial effects, it is still not clear whether vitamin D supplementation improves fertility or decreases the risk of adverse pregnancy outcomes such as low birth weight, pre-eclampsia and neonatal mortality, or reduces wheeze/asthma in the infants. Nevertheless, vitamin D supplementation in pregnant women is frequently required to achieve a sufficient vitamin D status as recommended by nutritional vitamin D guidelines. In this review, we provide an overview of systematic reviews, meta-analyses and large trials reporting clinical data on the role of vitamin D for fertility, pregnancy and lactation. |
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dc.language.iso |
eng |
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dc.publisher |
Basel : MDPI |
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dc.relation.ispartofseries |
International Journal of Environmental Research and Public Health 15 (2018) |
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dc.rights |
CC BY 4.0 Unported |
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dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
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dc.subject |
Vitamin D |
eng |
dc.subject |
gestational diabetes |
eng |
dc.subject |
pre-eclampsia |
eng |
dc.subject |
breast milk |
eng |
dc.subject |
vitamin D binding protein |
eng |
dc.subject |
DBP |
eng |
dc.subject |
brain |
eng |
dc.subject |
autism |
eng |
dc.subject |
25-hydroxyvitamin D |
eng |
dc.subject.ddc |
570 | Biowissenschaften, Biologie
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dc.title |
The Role of Vitamin D in Fertility and during Pregnancy and Lactation: A Review of Clinical Data |
eng |
dc.type |
Article |
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dc.type |
Text |
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dc.bibliographicCitation.firstPage |
2241 |
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dc.description.version |
publishedVersion |
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tib.accessRights |
frei zug�nglich |
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