A novel measuring chamber and automation platform for mammalian cell culture processes

Abstract

One of the biggest challenges of biotechnological production is the implementation of Process Analytical Technology (PAT) to obtain a highly automated, monitored and controlled process. Therefore the integration of suitable analytical sensors has to be faced at the earliest opportunity during process development. But sensor implementation for glass or disposable reactors encounters different issues. These systems are not designed to support well-established and standardized analytic ports for more complex probes used for stainless steel reactors. The here presented measuring chamber, combined with an automation platform enable an accelerated integration of PAT during all stages of process development for any reactor type.