Gittard, S.D.; Miller, P.R.; Boehm, R.D.; Ovsianikov, A.; Chichkov, B.N. et al.: Multiphoton microscopy of transdermal quantum dot delivery using two photon polymerization-fabricated polymer microneedles. In: Faraday Discussions 149 (2011), S. 171-185. DOI:
https://doi.org/10.1039/c005374k
Zusammenfassung: |
Due to their ability to serve as fluorophores and drug delivery vehicles, quantum dots are a powerful tool for theranostics-based clinical applications. In this study, microneedle devices for transdermal drug delivery were fabricated by means of two-photon polymerization of an acrylate-based polymer. We examined proliferation of cells on this polymer using neonatal human epidermal keratinocytes and human dermal fibroblasts. The microneedle device was used to inject quantum dots into porcine skin; imaging of the quantum dots was performed using multiphoton microscopy. © 2011 The Royal Society of Chemistry.
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Lizenzbestimmungen: |
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Publikationstyp: |
Article |
Publikationsstatus: |
publishedVersion |
Erstveröffentlichung: |
2011 |
Schlagwörter (englisch): |
polymer, quantum dot, animal, article, chemistry, cytology, drug delivery system, female, fluorescence microscopy, human, instrumentation, intradermal drug administration, keratinocyte, methodology, microinjection, needle, newborn, skin, swine, Administration, Cutaneous, Animals, Drug Delivery Systems, Female, Humans, Infant, Newborn, Keratinocytes, Microinjections, Microscopy, Fluorescence, Needles, Polymers, Quantum Dots, Skin, Swine
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Fachliche Zuordnung (DDC): |
540 | Chemie
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