Osteointegration of porous poly-ε-caprolactone-coated and previtalised magnesium implants in critically sized calvarial bone defects in the mouse model

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dc.identifier.uri http://dx.doi.org/10.15488/3373
dc.identifier.uri http://www.repo.uni-hannover.de/handle/123456789/3403
dc.contributor.author Grau, Michael
dc.contributor.author Seiler, Christian
dc.contributor.author Roland, Laura
dc.contributor.author Matena, Julia
dc.contributor.author Windhövel, Claudia
dc.contributor.author Teske, Michael
dc.contributor.author Escobar, Hugo Murua
dc.contributor.author Lüpke, Matthias
dc.contributor.author Seifert, Hermann
dc.contributor.author Gellrich, Nils-Claudius
dc.contributor.author Haferkamp, Heinz
dc.contributor.author Nolte, Ingo
dc.date.accessioned 2018-05-23T08:43:20Z
dc.date.available 2018-05-23T08:43:20Z
dc.date.issued 2017
dc.identifier.citation Grau, M.; Seiler, C.; Roland, L.; Matena, J.; Windhövel, C. et al.: Osteointegration of porous poly-ε-caprolactone-coated and previtalised magnesium implants in critically sized calvarial bone defects in the mouse model. In: Materials 11 (2017), Nr. 1, 6. DOI: https://doi.org/10.3390/ma11010006
dc.description.abstract Metallic biomaterials are widely used in maxillofacial surgery. While titanium is presumed to be the gold standard, magnesium-based implants are a current topic of interest and investigation due to their biocompatible, osteoconductive and degradable properties. This study investigates the effects of poly-ε-caprolactone-coated and previtalised magnesium implants on osteointegration within murine calvarial bone defects: After setting a 3 mm × 3 mm defect into the calvaria of 40 BALB/c mice the animals were treated with poly-ε-caprolactone-coated porous magnesium implants (without previtalisation or previtalised with either osteoblasts or adipose derived mesenchymal stem cells), porous Ti6Al4V implants or without any implant. To evaluate bone formation and implant degradation, micro-computertomographic scans were performed at day 0, 28, 56 and 84 after surgery. Additionally, histological thin sections were prepared and evaluated histomorphometrically. The outcomes revealed no significant differences within the differently treated groups regarding bone formation and the amount of osteoid. While the implant degradation resulted in implant shifting, both implant geometry and previtalisation appeared to have positive effects on vascularisation. Although adjustments in degradation behaviour and implant fixation are indicated, this study still considers magnesium as a promising alternative to titanium-based implants in maxillofacial surgery in future. © 2017 by the authors. eng
dc.language.iso eng
dc.publisher Basel : MDPI AG
dc.relation.ispartofseries Materials 11 (2017), Nr. 1
dc.rights CC BY 4.0
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject ADMSC eng
dc.subject Calvarial defect eng
dc.subject Implant eng
dc.subject In vivo small animal imaging eng
dc.subject Magnesium eng
dc.subject Micro-computed tomography eng
dc.subject Mouse eng
dc.subject Osteoblast eng
dc.subject Poly-caprolactone eng
dc.subject Previtalisation eng
dc.subject Aluminum alloys eng
dc.subject Animals eng
dc.subject Biocompatibility eng
dc.subject Biomaterials eng
dc.subject Bone eng
dc.subject Cell culture eng
dc.subject Computerized tomography eng
dc.subject Defects eng
dc.subject Implants (surgical) eng
dc.subject Mammals eng
dc.subject Metal implants eng
dc.subject Osteoblasts eng
dc.subject Stem cells eng
dc.subject Surgery eng
dc.subject Ternary alloys eng
dc.subject Titanium eng
dc.subject Titanium alloys eng
dc.subject Vanadium alloys eng
dc.subject ADMSC eng
dc.subject Calvarial defects eng
dc.subject In-vivo small animal imaging eng
dc.subject Microcomputed tomography eng
dc.subject Mouse eng
dc.subject Previtalisation eng
dc.subject Magnesium eng
dc.subject.ddc 600 | Technik ger
dc.title Osteointegration of porous poly-ε-caprolactone-coated and previtalised magnesium implants in critically sized calvarial bone defects in the mouse model
dc.type article
dc.type Text
dc.relation.issn 1996-1944
dc.relation.doi https://doi.org/10.3390/ma11010006
dc.bibliographicCitation.issue 1
dc.bibliographicCitation.volume 11
dc.bibliographicCitation.firstPage 6
dc.description.version publishedVersion
tib.accessRights frei zug�nglich


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