Trend tests for dichotomous endpoints with application to carcinogenicity studies

Neuhäuser, Markus; Hothorn, Ludwig A.

dc.identifier.uri	http://dx.doi.org/10.15488/3057
dc.identifier.uri	http://www.repo.uni-hannover.de/handle/123456789/3087
dc.contributor.author	Neuhäuser, Markus
dc.contributor.author	Hothorn, Ludwig A.
dc.date.accessioned	2018-03-01T14:03:51Z
dc.date.available	2018-03-01T14:03:51Z
dc.date.issued	1997
dc.identifier.citation	Neuhäuser, M.; Hothorn, L.A.: Trend tests for dichotomous endpoints with application to carcinogenicity studies. In: Therapeutic Innovation & Regulatory Science 31 (1997), Nr. 2, S. 463-469. DOI: https://doi.org/10.1177/009286159703100217
dc.description.abstract	A trend test for dichotomous endpoints analogous to the nonparametric Jonckheere test is developed. The power of this and all other single trend tests for dichotomous endpoints strongly depends on the shape of the dose response curve. Combined tests which have a stable power over a wide range of the ordered alternative are suggested. One can combine several contrast tests to a so-called adjustive test which is more powerful than a Cochran-Armitage test with equally-spaced scores. The latter was recommended by Armitage (1) in case there is no a priori knowledge of the type of the trend. © 1997, Drug Information Association. All rights reserved.	eng
dc.language.iso	eng
dc.publisher	London : SAGE Publications Ltd.
dc.relation.ispartofseries	Therapeutic Innovation & Regulatory Science 31 (1997), Nr. 2
dc.rights	Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
dc.subject	Carcinogenicity studies	eng
dc.subject	Dichotomous endpoints	eng
dc.subject	Order restricted alternative	eng
dc.subject	Trend tests	eng
dc.subject	Unknown shape	eng
dc.subject.ddc	610 \| Medizin, Gesundheit	ger
dc.title	Trend tests for dichotomous endpoints with application to carcinogenicity studies	eng
dc.type	Article
dc.type	Text
dc.relation.issn	2168-4790
dc.relation.doi	https://doi.org/10.1177/009286159703100217
dc.bibliographicCitation.issue	2
dc.bibliographicCitation.volume	31
dc.bibliographicCitation.firstPage	463
dc.bibliographicCitation.lastPage	469
dc.description.version	publishedVersion
tib.accessRights	frei zug�nglich