Multivariate many-to-one procedures with applications to preclinical trials

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dc.identifier.uri Kropf, Siegfried Hothorn, Ludwig A. Läuter, Jürgen 2018-03-01T12:10:31Z 2018-03-01T12:10:31Z 1997
dc.identifier.citation Kropf, S.; Hothorn, L.A.; Läuter, J.: Multivariate many-to-one procedures with applications to preclinical trials. In: Therapeutic Innovation & Regulatory Science 31 (1997), Nr. 2, S. 433-447. DOI:
dc.description.abstract Comparisons of several treatments with a control represent a standard situation in preclinical trials. Usually, they are considered with a single variable, resulting in multiple test procedures such as the Dunnett test (1). Here, the multivariate many-to-one problem is considered, where several variables are observed on each individual of the control and treatment groups. Classical MANOVA tests and their derivatives for the many-to-one problem require large sample sizes in order to be powerful if the dimension is high. In this paper, a new class of stabilized multivariate tests proposed by Läuter (2) and Läuter, Glimm, and Kropf (3) is extended to this special design. The new tests are based on linear scores which are derived in a certain way from the original variables. They utilize factorial relations among the variables. It is shown here that the procedures keep the multiple level. In simulation experiments several versions of multivariate tests are compared with each other. Standard approaches are included as well as different score versions and a comparison of Dunnett-like procedures with Bonferroni-type procedures. Generally, an improved power of the new tests compared to standard procedures is demonstrated. © 1997, Drug Information Association. All rights reserved. eng
dc.language.iso eng
dc.publisher London : SAGE Publications Ltd.
dc.relation.ispartofseries Therapeutic Innovation & Regulatory Science 31 (1997), Nr. 2
dc.rights Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
dc.subject Dunnett test eng
dc.subject Many-to-one procedures eng
dc.subject Multivariate tests eng
dc.subject Principal component test eng
dc.subject Stabilized scores eng
dc.subject.ddc 610 | Medizin, Gesundheit ger
dc.title Multivariate many-to-one procedures with applications to preclinical trials eng
dc.type Article
dc.type Text
dc.relation.issn 2168-4790
dc.bibliographicCitation.issue 2
dc.bibliographicCitation.volume 31
dc.bibliographicCitation.firstPage 433
dc.bibliographicCitation.lastPage 447
dc.description.version publishedVersion
tib.accessRights frei zug�nglich

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