dc.identifier.uri |
http://dx.doi.org/10.15488/3022 |
|
dc.identifier.uri |
http://www.repo.uni-hannover.de/handle/123456789/3052 |
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dc.contributor.author |
Hothorn, Ludwig A.
|
|
dc.date.accessioned |
2018-03-01T12:10:31Z |
|
dc.date.available |
2018-03-01T12:10:31Z |
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dc.date.issued |
1997 |
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dc.identifier.citation |
Hothorn, L.A.: Modifications of the closure principle for analyzing toxicological studies. In: Therapeutic Innovation & Regulatory Science 31 (1997), Nr. 2, S. 403-412. DOI: https://doi.org/10.1177/009286159703100211 |
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dc.description.abstract |
A Drug Information Association Workshop on “Statistical Methodology on Non-Clinical and Toxicological Studies” was held on March, 25-27, 1996. The purpose of this meeting was to discuss the appropriateness of current and new biostatistical methods in this field of drug development. This paper proposes a simple closure test for dose-response relationships under real data conditions. This approach takes into account deviation from variance homogeneity and monotonicity assumptions. Moreover, this approach can be easily adapted for “any” kind of two-sample tests, for example, nonparametric, dichotomous, censored, and so forth. Power was compared by a simulation study for selected conditions. © 1997, Drug Information Association. All rights reserved. |
eng |
dc.language.iso |
eng |
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dc.publisher |
London : SAGE Publications Ltd. |
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dc.relation.ispartofseries |
Therapeutic Innovation & Regulatory Science 31 (1997), Nr. 2 |
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dc.rights |
Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. |
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dc.subject |
Closure principle |
eng |
dc.subject |
MED |
eng |
dc.subject |
Toxicological studies |
eng |
dc.subject |
Trend test |
eng |
dc.subject.ddc |
610 | Medizin, Gesundheit
|
ger |
dc.title |
Modifications of the closure principle for analyzing toxicological studies |
eng |
dc.type |
Article |
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dc.type |
Text |
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dc.relation.issn |
2168-4790 |
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dc.relation.doi |
https://doi.org/10.1177/009286159703100211 |
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dc.bibliographicCitation.issue |
2 |
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dc.bibliographicCitation.volume |
31 |
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dc.bibliographicCitation.firstPage |
403 |
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dc.bibliographicCitation.lastPage |
412 |
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dc.description.version |
publishedVersion |
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tib.accessRights |
frei zug�nglich |
|