dc.identifier.uri |
http://dx.doi.org/10.15488/2981 |
|
dc.identifier.uri |
http://www.repo.uni-hannover.de/handle/123456789/3011 |
|
dc.contributor.author |
Hothorn, Ludwig A.
|
|
dc.contributor.author |
Martin, Ullrich
|
|
dc.date.accessioned |
2018-02-28T13:27:42Z |
|
dc.date.available |
2018-02-28T13:27:42Z |
|
dc.date.issued |
1997 |
|
dc.identifier.citation |
Hothorn, L.A.; Martin, U.: Application of adaptive interim analysis in pharmacology. In: Therapeutic Innovation & Regulatory Science 31 (1997), Nr. 2, S. 615-619. DOI: https://doi.org/10.1177/009286159703100229 |
|
dc.description.abstract |
A Drug Information Association Workshop on “Statistical Methodology on Non-Clinical and Toxicological Studies” was held March 25–27, 1996. The purpose of this meeting was to discuss the appropriateness of current and new biostatistical methods in this field of drug development. This paper describes the application of adaptive interim analysis in pharmacological studies. Bauer and Köhne (1) published a two-step approach in the case of unknown a priori information. This approach is now widely used for clinical trails. Here, the advantages of use in some pharmacological studies will be discussed. © 1997, Drug Information Association. All rights reserved. |
eng |
dc.language.iso |
eng |
|
dc.publisher |
London : SAGE Publications Ltd. |
|
dc.relation.ispartofseries |
Therapeutic Innovation & Regulatory Science 31 (1997), Nr. 2 |
|
dc.rights |
Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. |
|
dc.subject |
Interim analysis |
eng |
dc.subject |
Pharmacological studies |
eng |
dc.subject.ddc |
610 | Medizin, Gesundheit
|
ger |
dc.title |
Application of adaptive interim analysis in pharmacology |
eng |
dc.type |
Article |
|
dc.type |
Text |
|
dc.relation.issn |
2168-4790 |
|
dc.relation.doi |
https://doi.org/10.1177/009286159703100229 |
|
dc.bibliographicCitation.issue |
2 |
|
dc.bibliographicCitation.volume |
31 |
|
dc.bibliographicCitation.firstPage |
615 |
|
dc.bibliographicCitation.lastPage |
619 |
|
dc.description.version |
publishedVersion |
|
tib.accessRights |
frei zug�nglich |
|