dc.identifier.uri |
http://dx.doi.org/10.15488/2737 |
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dc.identifier.uri |
http://www.repo.uni-hannover.de/handle/123456789/2763 |
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dc.contributor.author |
Wolters, Maike
|
|
dc.contributor.author |
Hahn, Andreas
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|
dc.date.accessioned |
2018-02-09T09:27:53Z |
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dc.date.available |
2018-02-09T09:27:53Z |
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dc.date.issued |
2004 |
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dc.identifier.citation |
Wolters, M.; Hahn, A.: LDL Susceptibility to copper-induced oxidation after administration of a single dose of free or esterified beta-cryptoxanthin. In: Annals of Nutrition and Metabolism 48 (2004), Nr. 3, S. 163-168. DOI: https://doi.org/10.1159/000078380 |
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dc.description.abstract |
Background: The oxidative modification of LDL is believed to be an initial step in atherosclerosis. Thus, antioxidative substances such as carotenoids may have a role in the prevention of coronary heart disease. We examined the susceptibility of LDL to Cu2+ oxidation in young adults before and after a single dose of β-cryptoxanthin. Methods: 1.3 mg of β-cryptoxanthin was administered to 12 apparently healthy young volunteers. Six of the volunteers received esters, the other six free β-cryptoxanthin. The plasma concentration of β-cryptoxanthin and the susceptibility of LDL to copper-induced oxidation ex vivo in terms of the duration of lag time were measured before and 12 h after β-cryptoxanthin ingestion. Results: A single dose of β-cryptoxanthin significantly increased the mean plasma β-cryptoxanthin concentration and the mean cholesterol adjusted β-cryptoxanthin concentration by 117 and 133%, respectively. No effect on the length of lag time was assessed. However, in LDL isolated from plasma 12 h after β-cryptoxanthin administration the lengths of lag time correlated significantly with the plasma β-cryptoxanthin concentration and with the cholesterol adjusted β-cryptoxanthin levels. The lag time did not differ significantly between volunteers who received esters and those who received the same dosage as free β-cryptoxanthin. At both measuring points, smokers, male volunteers and women using oral contraceptives tended to exhibit lower β-cryptoxanthin concentrations and lower cholesterol adjusted β-cryptoxanthin concentrations as well as increased LDL oxidizability compared to nonsmokers and women not using oral contraceptives. Conclusion: A single dose of β-cryptoxanthin does not enhance the duration of LDL lag time ex vivo in healthy young subjects. Copyright © 2004 S. Karger AG, Basel. |
eng |
dc.language.iso |
eng |
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dc.publisher |
Basel : S. Karger AG |
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dc.relation.ispartofseries |
Annals of Nutrition and Metabolism 48 (2004), Nr. 3 |
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dc.rights |
Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. |
|
dc.subject |
Beta-cryptoxanthin |
eng |
dc.subject |
Beta-cryptoxanthin ester |
eng |
dc.subject |
Low-density lipoprotein |
eng |
dc.subject |
Low-density lipoprotein oxidation |
eng |
dc.subject |
beta cryptoxanthin |
eng |
dc.subject |
cholesterol |
eng |
dc.subject |
copper |
eng |
dc.subject |
cryptoxanthin |
eng |
dc.subject |
ester |
eng |
dc.subject |
low density lipoprotein |
eng |
dc.subject |
oral contraceptive agent |
eng |
dc.subject |
unclassified drug |
eng |
dc.subject |
adult |
eng |
dc.subject |
article |
eng |
dc.subject |
clinical trial |
eng |
dc.subject |
comparative study |
eng |
dc.subject |
controlled clinical trial |
eng |
dc.subject |
controlled study |
eng |
dc.subject |
correlation analysis |
eng |
dc.subject |
drug blood level |
eng |
dc.subject |
drug effect |
eng |
dc.subject |
esterification |
eng |
dc.subject |
female |
eng |
dc.subject |
human |
eng |
dc.subject |
lipid oxidation |
eng |
dc.subject |
male |
eng |
dc.subject |
measurement |
eng |
dc.subject |
normal human |
eng |
dc.subject |
oral contraception |
eng |
dc.subject |
priority journal |
eng |
dc.subject |
randomized controlled trial |
eng |
dc.subject |
smoking |
eng |
dc.subject |
statistical significance |
eng |
dc.subject |
time |
eng |
dc.subject |
Adult |
eng |
dc.subject |
Arteriosclerosis |
eng |
dc.subject |
beta Carotene |
eng |
dc.subject |
Contraceptive Agents, Female |
eng |
dc.subject |
Copper |
eng |
dc.subject |
Esterification |
eng |
dc.subject |
Female |
eng |
dc.subject |
Humans |
eng |
dc.subject |
Lipoproteins, LDL |
eng |
dc.subject |
Male |
eng |
dc.subject |
Oxidation-Reduction |
eng |
dc.subject |
Smoking |
eng |
dc.subject |
Time Factors |
eng |
dc.subject |
Xanthophylls |
eng |
dc.subject.ddc |
610 | Medizin, Gesundheit
|
ger |
dc.title |
LDL Susceptibility to copper-induced oxidation after administration of a single dose of free or esterified beta-cryptoxanthin |
|
dc.type |
Article |
|
dc.type |
Text |
|
dc.relation.issn |
0250-6807 |
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dc.relation.doi |
https://doi.org/10.1159/000078380 |
|
dc.bibliographicCitation.issue |
3 |
|
dc.bibliographicCitation.volume |
48 |
|
dc.bibliographicCitation.firstPage |
163 |
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dc.bibliographicCitation.lastPage |
168 |
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dc.description.version |
publishedVersion |
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tib.accessRights |
frei zug�nglich |
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