Abstract: | |
Background: The oxidative modification of LDL is believed to be an initial step in atherosclerosis. Thus, antioxidative substances such as carotenoids may have a role in the prevention of coronary heart disease. We examined the susceptibility of LDL to Cu2+ oxidation in young adults before and after a single dose of β-cryptoxanthin. Methods: 1.3 mg of β-cryptoxanthin was administered to 12 apparently healthy young volunteers. Six of the volunteers received esters, the other six free β-cryptoxanthin. The plasma concentration of β-cryptoxanthin and the susceptibility of LDL to copper-induced oxidation ex vivo in terms of the duration of lag time were measured before and 12 h after β-cryptoxanthin ingestion. Results: A single dose of β-cryptoxanthin significantly increased the mean plasma β-cryptoxanthin concentration and the mean cholesterol adjusted β-cryptoxanthin concentration by 117 and 133%, respectively. No effect on the length of lag time was assessed. However, in LDL isolated from plasma 12 h after β-cryptoxanthin administration the lengths of lag time correlated significantly with the plasma β-cryptoxanthin concentration and with the cholesterol adjusted β-cryptoxanthin levels. The lag time did not differ significantly between volunteers who received esters and those who received the same dosage as free β-cryptoxanthin. At both measuring points, smokers, male volunteers and women using oral contraceptives tended to exhibit lower β-cryptoxanthin concentrations and lower cholesterol adjusted β-cryptoxanthin concentrations as well as increased LDL oxidizability compared to nonsmokers and women not using oral contraceptives. Conclusion: A single dose of β-cryptoxanthin does not enhance the duration of LDL lag time ex vivo in healthy young subjects. Copyright © 2004 S. Karger AG, Basel.
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License of this version: | Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. |
Publication type: | Article |
Publishing status: | publishedVersion |
Publication date: | 2004 |
Keywords english: | Beta-cryptoxanthin, Beta-cryptoxanthin ester, Low-density lipoprotein, Low-density lipoprotein oxidation, beta cryptoxanthin, cholesterol, copper, cryptoxanthin, ester, low density lipoprotein, oral contraceptive agent, unclassified drug, adult, article, clinical trial, comparative study, controlled clinical trial, controlled study, correlation analysis, drug blood level, drug effect, esterification, female, human, lipid oxidation, male, measurement, normal human, oral contraception, priority journal, randomized controlled trial, smoking, statistical significance, time, Adult, Arteriosclerosis, beta Carotene, Contraceptive Agents, Female, Copper, Esterification, Female, Humans, Lipoproteins, LDL, Male, Oxidation-Reduction, Smoking, Time Factors, Xanthophylls |
DDC: | 610 | Medizin, Gesundheit |