Effects of degradable Mg-Ca alloys on dendritic cell function

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dc.identifier.uri http://dx.doi.org/10.15488/2302
dc.identifier.uri http://www.repo.uni-hannover.de/handle/123456789/2328
dc.contributor.author Feser, K.
dc.contributor.author Kietzmann, M.
dc.contributor.author Bäumer, W.
dc.contributor.author Krause, C.
dc.contributor.author Bach, F.W.
dc.date.accessioned 2017-11-17T08:34:57Z
dc.date.available 2017-11-17T08:34:57Z
dc.date.issued 2011
dc.identifier.citation Feser, K.; Kietzmann, M.; Bäumer, W.; Krause, C.; Bach, F.W.: Effects of degradable Mg-Ca alloys on dendritic cell function. In: Journal of Biomaterials Applications 25 (2011), Nr. 7, S. 685-697. DOI: https://doi.org/10.1177/0885328209360424
dc.description.abstract Degradable magnesium alloys are new materials for implants used in orthopedic and trauma surgery. The aim of this study was to investigate the influence of degradable magnesium alloys on the function of dendritic cells (DC) as these cells represent the major antigen presenting cells of the body. MgP (pure magnesium), MgCa 0.6 (0.6% calcium), MgCa 0.8 (0.8% calcium), MgCa 1.0 (1% calcium), and MgCa 1.2 (1.2% calcium) alloys were degraded in cell culture medium. In parallel, murine bone marrow-derived DC were incubated with increasing concentrations (0.1-10 mmol/L) of magnesium chloride and calcium chloride, respectively. Incubation of DC with degradation media over 6 days had no influence on cell viability and only marginal influence on DC migration. Also, the production of TNFα and expression of CD86 was not enhanced by incubation with degraded magnesium alloys. The mixed leukocyte reaction revealed that there was also no increase of the T-cell proliferation in comparison to untreated controls. However, there was a trend toward macrophage development at the expense of DC expansion and an enhanced DC migration was induced by incubation with higher magnesium concentrations. Particularly the latter should be verified in in vivo experiments. © The Author(s), 2010. eng
dc.language.iso eng
dc.publisher London : SAGE Publications Ltd.
dc.relation.ispartofseries Journal of Biomaterials Applications 25 (2011), Nr. 7
dc.rights Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
dc.subject dendritic cells eng
dc.subject macrophages eng
dc.subject magnesium alloys eng
dc.subject T-cell activation eng
dc.subject viability eng
dc.subject Antigen presenting cells eng
dc.subject Bone marrow eng
dc.subject Cell viability eng
dc.subject Dendritic cells eng
dc.subject In-cell eng
dc.subject In-vivo experiments eng
dc.subject Magnesium chlorides eng
dc.subject Magnesium concentrations eng
dc.subject New material eng
dc.subject Pure magnesium eng
dc.subject T-cell activation eng
dc.subject Untreated control eng
dc.subject viability eng
dc.subject Alloys eng
dc.subject Calcium eng
dc.subject Calcium alloys eng
dc.subject Calcium chloride eng
dc.subject Cell proliferation eng
dc.subject Macrophages eng
dc.subject Magnesium eng
dc.subject Magnesium alloys eng
dc.subject Cell culture eng
dc.subject alloy eng
dc.subject biomaterial eng
dc.subject calcium eng
dc.subject CD86 antigen eng
dc.subject magnesium eng
dc.subject animal eng
dc.subject article eng
dc.subject cell culture eng
dc.subject cell differentiation eng
dc.subject cell motion eng
dc.subject cell survival eng
dc.subject cytology eng
dc.subject dendritic cell eng
dc.subject female eng
dc.subject immunology eng
dc.subject lymphocyte activation eng
dc.subject macrophage eng
dc.subject metabolism eng
dc.subject mouse eng
dc.subject Alloys eng
dc.subject Animals eng
dc.subject Antigens, CD86 eng
dc.subject Biocompatible Materials eng
dc.subject Calcium eng
dc.subject Cell Differentiation eng
dc.subject Cell Movement eng
dc.subject Cell Survival eng
dc.subject Cells, Cultured eng
dc.subject Dendritic Cells eng
dc.subject Female eng
dc.subject Lymphocyte Activation eng
dc.subject Macrophages eng
dc.subject Magnesium eng
dc.subject Mice eng
dc.subject.ddc 610 | Medizin, Gesundheit ger
dc.title Effects of degradable Mg-Ca alloys on dendritic cell function
dc.type article
dc.type Text
dc.relation.issn 0885-3282
dc.relation.doi https://doi.org/10.1177/0885328209360424
dc.bibliographicCitation.issue 7
dc.bibliographicCitation.volume 25
dc.bibliographicCitation.firstPage 685
dc.bibliographicCitation.lastPage 697
dc.description.version publishedVersion
tib.accessRights frei zug�nglich


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