Biodegradation of a magnesium alloy implant in the intercondylar femoral notch showed an appropriate response to the synovial membrane in a rabbit model in vivo

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dc.identifier.uri http://dx.doi.org/10.15488/2293
dc.identifier.uri http://www.repo.uni-hannover.de/handle/123456789/2319
dc.contributor.author Ezechieli, Marco
dc.contributor.author Diekmann, Julia
dc.contributor.author Weizbauer, Andreas
dc.contributor.author Becher, Christoph
dc.contributor.author Willbold, Elmar
dc.contributor.author Helmecke, Patrick
dc.contributor.author Lucas, Arne
dc.contributor.author Schavan, Robert
dc.contributor.author Windhagen, Henning
dc.date.accessioned 2017-11-17T08:10:22Z
dc.date.available 2017-11-17T08:10:22Z
dc.date.issued 2014
dc.identifier.citation Ezechieli, M.; Diekmann, J.; Weizbauer, A.; Becher, C.; Willbold, E. et al.: Biodegradation of a magnesium alloy implant in the intercondylar femoral notch showed an appropriate response to the synovial membrane in a rabbit model in vivo. In: Journal of Biomaterials Applications 29 (2014), Nr. 2, S. 291-302. DOI: https://doi.org/10.1177/0885328214523322
dc.description.abstract Degradable magnesium alloys are promising biomaterials for orthopedic applications. The aim of this study was to evaluate the potential effects on both the synovial membrane (synovialis) and the synovial fluid (synovia) of the degradation products of a MgYREZr-pin implanted in the intercondylar femoral notch in a rabbit model. Thirty-six animals were randomized into two groups (MgYREZr or Ti6Al4V alloy) of 18 animals each. Each group was then divided into three subgroups with implantation periods of 1, 4, and 12 weeks, with six animals in each subgroup. The initial inflammatory reaction caused by the surgical trauma declined after 12 weeks of implantation, and elucidated a progressive recovery of the synovial membrane. Compared with control Ti6Al4V pins, there were no significant differences between the groups. However, after 12 weeks, recovery of the synovial membrane was more advanced in the titanium group, in which 92% showed no signs of synovitis, than in the magnesium group. A cytotoxicity test with L929 cells and human osteoblasts (HOB) was also conducted, according to EN ISO 10993-5/12, and no toxic leachable products were observed after 24 h of incubation. In conclusion, the MgYREZr alloy seems to be a suitable material for intra-articular degradable implants. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav. eng
dc.language.iso eng
dc.publisher London : SAGE Publications Ltd.
dc.relation.ispartofseries Journal of Biomaterials Applications 29 (2014), Nr. 2
dc.rights Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
dc.subject biocompatibility eng
dc.subject cytotoxicity test eng
dc.subject degradable eng
dc.subject Magnesium alloy eng
dc.subject synovitis eng
dc.subject Animals eng
dc.subject Biocompatibility eng
dc.subject Biodegradation eng
dc.subject Biological materials eng
dc.subject Degradation eng
dc.subject Neural prostheses eng
dc.subject Osteoblasts eng
dc.subject Cytotoxicity test eng
dc.subject degradable eng
dc.subject Degradation products eng
dc.subject Implantation periods eng
dc.subject Inflammatory reaction eng
dc.subject Leachable products eng
dc.subject Orthopedic applications eng
dc.subject synovitis eng
dc.subject Magnesium alloys eng
dc.subject alloy eng
dc.subject biomaterial eng
dc.subject magnesium eng
dc.subject titanium eng
dc.subject animal experiment eng
dc.subject animal model eng
dc.subject animal tissue eng
dc.subject anterior cruciate ligament eng
dc.subject article eng
dc.subject biocompatibility eng
dc.subject biodegradation eng
dc.subject controlled study eng
dc.subject cytotoxicity test eng
dc.subject female eng
dc.subject implantation eng
dc.subject incubation time eng
dc.subject inflammation eng
dc.subject nonhuman eng
dc.subject orthopedic implant eng
dc.subject osteoblast eng
dc.subject priority journal eng
dc.subject surgical injury eng
dc.subject synovial fluid eng
dc.subject synovitis eng
dc.subject synovium eng
dc.subject.ddc 610 | Medizin, Gesundheit ger
dc.title Biodegradation of a magnesium alloy implant in the intercondylar femoral notch showed an appropriate response to the synovial membrane in a rabbit model in vivo
dc.type article
dc.type Text
dc.relation.issn 0885-3282
dc.relation.doi https://doi.org/10.1177/0885328214523322
dc.bibliographicCitation.issue 2
dc.bibliographicCitation.volume 29
dc.bibliographicCitation.firstPage 291
dc.bibliographicCitation.lastPage 302
dc.description.version publishedVersion
tib.accessRights frei zug�nglich


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