dc.identifier.uri |
http://dx.doi.org/10.15488/2159 |
|
dc.identifier.uri |
http://www.repo.uni-hannover.de/handle/123456789/2184 |
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dc.contributor.author |
Krause, Andreas
|
|
dc.contributor.author |
Kirschning, Andreas
|
|
dc.contributor.author |
Dräger, Gerald
|
|
dc.date.accessioned |
2017-10-30T13:12:54Z |
|
dc.date.available |
2017-10-30T13:12:54Z |
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dc.date.issued |
2012 |
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dc.identifier.citation |
Krause, A.; Kirschning, A.; Dräger, G.: Bioorthogonal metal-free click-ligation of cRGD-pentapeptide to alginate. In: Organic and Biomolecular Chemistry 10 (2012), Nr. 29, S. 5547-5553. DOI: https://doi.org/10.1039/c2ob25604e |
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dc.description.abstract |
Click reactions have become very common and powerful ligation techniques, of which 1,3-dipolar cycloadditions have most frequently been employed. Since metal-mediated cycloadditions are incompatible in biomedical applications due to toxicity issues associated with transition metals like copper, metal-free variants provide important alternatives. The metal-free conjugation process is studied in detail with special emphasis put on the reaction progress. This report unfolds the first aqueous metal-free "click" conjugation of a cyclic RGD-pentapeptide with the biomacromolecule alginate, creating a "smart" bioactive polymer with potential applications in biomedicine. © 2012 The Royal Society of Chemistry. |
eng |
dc.language.iso |
eng |
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dc.publisher |
Cambridge : Royal Society of Chemistry |
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dc.relation.ispartofseries |
Organic and Biomolecular Chemistry 10 (2012), Nr. 29 |
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dc.rights |
Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. |
|
dc.subject |
1 ,3-dipolar cycloadditions |
eng |
dc.subject |
Bioactive polymers |
eng |
dc.subject |
Biomacromolecule |
eng |
dc.subject |
Biomedical applications |
eng |
dc.subject |
Conjugation process |
eng |
dc.subject |
Cycloadditions |
eng |
dc.subject |
Potential applications |
eng |
dc.subject |
Reaction progress |
eng |
dc.subject |
Cycloaddition |
eng |
dc.subject |
Medical applications |
eng |
dc.subject |
Transition metals |
eng |
dc.subject |
alginic acid |
eng |
dc.subject |
copper |
eng |
dc.subject |
cyclic arginine glycine aspartic acid peptide |
eng |
dc.subject |
cyclic arginine-glycine-aspartic acid peptide |
eng |
dc.subject |
cyclopeptide |
eng |
dc.subject |
glucuronic acid |
eng |
dc.subject |
hexuronic acid |
eng |
dc.subject |
polymer |
eng |
dc.subject |
article |
eng |
dc.subject |
chemistry |
eng |
dc.subject |
click chemistry |
eng |
dc.subject |
ligation |
eng |
dc.subject |
Alginates |
eng |
dc.subject |
Click Chemistry |
eng |
dc.subject |
Copper |
eng |
dc.subject |
Glucuronic Acid |
eng |
dc.subject |
Hexuronic Acids |
eng |
dc.subject |
Ligation |
eng |
dc.subject |
Peptides, Cyclic |
eng |
dc.subject |
Polymers |
eng |
dc.subject.ddc |
540 | Chemie
|
ger |
dc.title |
Bioorthogonal metal-free click-ligation of cRGD-pentapeptide to alginate |
eng |
dc.type |
Article |
|
dc.type |
Text |
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dc.relation.issn |
1477-0520 |
|
dc.relation.doi |
https://doi.org/10.1039/c2ob25604e |
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dc.bibliographicCitation.issue |
29 |
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dc.bibliographicCitation.volume |
10 |
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dc.bibliographicCitation.firstPage |
5547 |
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dc.bibliographicCitation.lastPage |
5553 |
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dc.description.version |
publishedVersion |
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tib.accessRights |
frei zug�nglich |
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