Krause, A.; Kirschning, A.; Dräger, G.: Bioorthogonal metal-free click-ligation of cRGD-pentapeptide to alginate. In: Organic and Biomolecular Chemistry 10 (2012), Nr. 29, S. 5547-5553. DOI:
https://doi.org/10.1039/c2ob25604e
Zusammenfassung: |
Click reactions have become very common and powerful ligation techniques, of which 1,3-dipolar cycloadditions have most frequently been employed. Since metal-mediated cycloadditions are incompatible in biomedical applications due to toxicity issues associated with transition metals like copper, metal-free variants provide important alternatives. The metal-free conjugation process is studied in detail with special emphasis put on the reaction progress. This report unfolds the first aqueous metal-free "click" conjugation of a cyclic RGD-pentapeptide with the biomacromolecule alginate, creating a "smart" bioactive polymer with potential applications in biomedicine. © 2012 The Royal Society of Chemistry.
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Lizenzbestimmungen: |
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Publikationstyp: |
Article |
Publikationsstatus: |
publishedVersion |
Erstveröffentlichung: |
2012 |
Schlagwörter (englisch): |
1 ,3-dipolar cycloadditions, Bioactive polymers, Biomacromolecule, Biomedical applications, Conjugation process, Cycloadditions, Potential applications, Reaction progress, Cycloaddition, Medical applications, Transition metals, alginic acid, copper, cyclic arginine glycine aspartic acid peptide, cyclic arginine-glycine-aspartic acid peptide, cyclopeptide, glucuronic acid, hexuronic acid, polymer, article, chemistry, click chemistry, ligation, Alginates, Click Chemistry, Copper, Glucuronic Acid, Hexuronic Acids, Ligation, Peptides, Cyclic, Polymers
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Fachliche Zuordnung (DDC): |
540 | Chemie
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