Therapy preferences of patients with lung and colon cancer: A discrete choice experiment

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dc.identifier.uri Schmidt, Katharina Damm, Kathrin Vogel, Arndt Golpon, Heiko Manns, Michael P. Welte, Tobias Schulenburg, Johann-Matthias Graf von der 2017-10-24T08:25:17Z 2017-10-24T08:25:17Z 2017
dc.identifier.citation Schmidt, K.; Damm, K.; Vogel, A.; Golpon, H.; Manns, M.P. et al.: Therapy preferences of patients with lung and colon cancer: A discrete choice experiment. In: Patient Preference and Adherence 11 (2017), S. 1647-1656. DOI:
dc.description.abstract Objectives: There is increasing interest in studies that examine patient preferences to measure health-related outcomes. Understanding patients’ preferences can improve the treatment process and is particularly relevant for oncology. In this study, we aimed to identify the subgroup-specific treatment preferences of German patients with lung cancer (LC) or colorectal cancer (CRC). Methods: Six discrete choice experiment (DCE) attributes were established on the basis of a systematic literature review and qualitative interviews. The DCE analyses comprised generalized linear mixed-effects model and latent class mixed logit model. Results: The study cohort comprised 310 patients (194 with LC, 108 with CRC, 8 with both types of cancer) with a median age of 63 (SD =10.66) years. The generalized linear mixed-effects model showed a significant (P<0.05) degree of association for all of the tested attributes. “Strongly increased life expectancy” was the attribute given the greatest weight by all patient groups. Using latent class mixed logit model analysis, we identified three classes of patients. Patients who were better informed tended to prefer a more balanced relationship between length and health-related quality of life (HRQoL) than those who were less informed. Class 2 (LC patients with low HRQoL who had undergone surgery) gave a very strong weighting to increased length of life. We deduced from Class 3 patients that those with a relatively good life expectancy (CRC compared with LC) gave a greater weight to moderate effects on HRQoL than to a longer life. Conclusion: Overall survival was the most important attribute of therapy for patients with LC or CRC. Differences in treatment preferences between subgroups should be considered in regard to treatment and development of guidelines. Patients’ preferences were not affected by sex or age, but were affected by the cancer type, HRQoL, surgery status, and the main source of information on the disease. eng
dc.language.iso eng
dc.publisher Macclesfield : Dove Medical Press
dc.relation.ispartofseries Patient Preference and Adherence 11 (2017)
dc.rights CC BY-NC 3.0 Unported
dc.subject Colorectal cancer eng
dc.subject Germany eng
dc.subject Latent class model eng
dc.subject Lung cancer eng
dc.subject Multi-criteria decision making eng
dc.subject Patient preferences eng
dc.subject.ddc 610 | Medizin, Gesundheit ger
dc.title Therapy preferences of patients with lung and colon cancer: A discrete choice experiment eng
dc.type article
dc.type Text
dc.relation.issn 1177-889X
dc.bibliographicCitation.volume 11
dc.bibliographicCitation.firstPage 1647
dc.bibliographicCitation.lastPage 1656
dc.description.version publishedVersion
tib.accessRights frei zug�nglich

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