Antibacterial Silica Nanoparticles with PH-Sensitive Release Properties as Fillers for Dental Composite Materials

Abstract

Silica nanoparticles with nanopores were used to incorporate antimicrobial agents, like silver nanoparticles or chlorhexidine. By the functionalization of the particles with different organosilanes a controlled drug release is possible. A stimuli-response system was able to react to acidic conditions as caused by an infection and to release the drugs only when necessary. These particles could be incorporated into dental composite materials to prevent infections or periimplantitis.