Tumor homing and penetrating peptide-conjugated niosomes as multi-drug carriers for tumor-targeted drug delivery

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dc.identifier.uri http://dx.doi.org/10.15488/1807
dc.identifier.uri http://www.repo.uni-hannover.de/handle/123456789/1832
dc.contributor.author Ag Seleci, Didem
dc.contributor.author Seleci, Muharre,
dc.contributor.author Stahl, Frank
dc.contributor.author Scheper, Thomas
dc.date.accessioned 2017-08-30T11:46:24Z
dc.date.available 2017-08-30T11:46:24Z
dc.date.issued 2017
dc.identifier.citation Ag Seleci, D.; Seleci, M.; Stahl, F.; Scheper, T.: Tumor homing and penetrating peptide-conjugated niosomes as multi-drug carriers for tumor-targeted drug delivery. In: RSC Advances 7 (2017), Nr. 53, S. 33378-33384. DOI: https://doi.org/10.1039/c7ra05071b
dc.description.abstract The development of nanoscale drug delivery systems, which can mediate efficient tumor targeting together with high cellular internalization, is crucial for glioma treatment. The combination of therapeutic agents in nanoparticles provides synergistic effects and allows further surface modifications with targeting ligands for specific glioma therapy. To achieve this goal, both doxorubicin and curcumin were encapsulated in polyethylene glycolated niosomes (PEGNIO). The surface of co-drug loaded PEGNIO was modified with tumor homing and penetrating peptide (tLyp-1). Physicochemical properties were determined via dynamic light scattering (DLS) and spectral analysis. Moreover, flow cytometry studies were performed to examine the specific cellular uptake of the tLyp-1 targeted niosomal formulation. In vitro cytotoxicity and inhibition of tumor-like spheroids growth were investigated on human glioblastoma (U87) and human mesenchymal stem cells (hMSC) cells. The results clearly indicated that the strategy by co-administration of doxorubicin and curcumin with tLyp-1 functionalized niosomes could significantly improve anti-glioma treatment. eng
dc.description.sponsorship DFG/EXC/REBIRTH
dc.description.sponsorship Konrad Adenauer Foundation
dc.language.iso eng
dc.publisher Cambridge : Royal Society of Chemistry
dc.relation.ispartofseries RSC Advances 7 (2017), Nr. 53
dc.rights CC BY-NC 3.0
dc.rights.uri https://creativecommons.org/licenses/by-nc/3.0/
dc.subject Cell culture eng
dc.subject Dynamic light scattering eng
dc.subject Peptides eng
dc.subject Spectrum analysis eng
dc.subject Stem cells eng
dc.subject Tumors eng
dc.subject Cellular internalization eng
dc.subject Drug delivery system eng
dc.subject Human mesenchymal stem cells eng
dc.subject Physicochemical property eng
dc.subject Synergistic effect eng
dc.subject Targeting ligands eng
dc.subject Therapeutic agents eng
dc.subject Tumor-targeted drug deliveries eng
dc.subject Targeted drug delivery eng
dc.subject.ddc 540 | Chemie ger
dc.title Tumor homing and penetrating peptide-conjugated niosomes as multi-drug carriers for tumor-targeted drug delivery
dc.type article
dc.type Text
dc.relation.issn 2046-2069
dc.relation.doi https://doi.org/10.1039/c7ra05071b
dc.bibliographicCitation.issue 53
dc.bibliographicCitation.volume 7
dc.bibliographicCitation.firstPage 33378
dc.bibliographicCitation.lastPage 33384
dc.description.version publishedVersion
tib.accessRights frei zug�nglich

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