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dc.identifier.uri Zhao, H.-B. Kikuchi, T. Ngezahayo, Anaclet White, T.W. 2017-07-04T10:06:08Z 2017-07-04T10:06:08Z 2006
dc.identifier.citation Zhao, H.-B.; Kikuchi, T.; Ngezahayo, A.; White, T.W.: Gap Junctions and Cochlear Homeostasis. In: Journal of Membrane Biology 209 (2006), S. 177-186. DOI:
dc.description.abstract Gap junctions play a critical role in hearing and mutations in connexin genes cause a high incidence of human deafness. Pathogenesis mainly occurs in the cochlea, where gap junctions form extensive networks between non-sensory cells that can be divided into two independent gap junction systems, the epithelial cell gap junction system and the connective tissue cell gap junction system. At least four different connexins have been reported to be present in the mammalian inner ear, and gap junctions are thought to provide a route for recycling potassium ions that pass through the sensory cells during the mechanosensory transduction process back to the endolymph. Here we review the cochlear gap junction networks and their hypothesized role in potassium ion recycling mechanism, pharmacological and physiological gating of cochlear connexins, animal models harboring connexin mutations and functional studies of mutant channels that cause human deafness. These studies elucidate gap junction functions in the cochlea and also provide insight for understanding the pathogenesis of this common hereditary deafness induced by connexin mutations. The final publication is available at Springer via eng
dc.description.sponsorship NIH/DC06652
dc.description.sponsorship NIH/DC05989
dc.language.iso eng
dc.publisher Heidelberg : Springer Verlag
dc.relation.ispartofseries Journal of Membrane Biology 209 (2006)
dc.rights Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden.
dc.subject Cochlea eng
dc.subject Supporting cell eng
dc.subject Gap junction eng
dc.subject Connexin eng
dc.subject Potassium eng
dc.subject Deafness eng
dc.subject.ddc 570 | Biowissenschaften, Biologie ger
dc.title Gap Junctions and Cochlear Homeostasis
dc.type Article
dc.type Text
dc.relation.issn 0022-2631
dc.bibliographicCitation.volume 209
dc.bibliographicCitation.firstPage 177
dc.bibliographicCitation.lastPage 186
dc.description.version acceptedVersion
tib.accessRights frei zug�nglich

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