dc.identifier.uri |
http://dx.doi.org/10.15488/16809 |
|
dc.identifier.uri |
https://www.repo.uni-hannover.de/handle/123456789/16936 |
|
dc.contributor.author |
Zhang, Ningning
|
|
dc.contributor.author |
Domínguez de María, Pablo
|
|
dc.contributor.author |
Kara, Selin
|
|
dc.date.accessioned |
2024-03-27T07:47:12Z |
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dc.date.available |
2024-03-27T07:47:12Z |
|
dc.date.issued |
2024 |
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dc.identifier.citation |
Zhang, N.; Domínguez de María, P.; Kara, S.: Biocatalysis for the Synthesis of Active Pharmaceutical Ingredients in Deep Eutectic Solvents: State-of-the-Art and Prospects. In: Catalysts 14 (2024), Nr. 1, 84. DOI: https://doi.org/10.3390/catal14010084 |
|
dc.description.abstract |
Biocatalysis holds immense potential for pharmaceutical development as it enables synthetic routes to various chiral building blocks with unparalleled selectivity. Therein, solvent and water use account for a large contribution to the environmental impact of the reactions. In the spirit of Green Chemistry, a transition from traditional highly diluted aqueous systems to intensified non-aqueous media to overcome limitations (e.g., water shortages, recalcitrant wastewater treatments, and low substrate loadings) has been observed. Benefiting from the spectacular advances in various enzyme stabilization techniques, a plethora of biotransformations in non-conventional media have been established. Deep eutectic solvents (DESs) emerge as a sort of (potentially) greener non-aqueous medium with increasing use in biocatalysis. This review discusses the state-of-the-art of biotransformations in DESs with a focus on biocatalytic pathways for the synthesis of active pharmaceutical ingredients (APIs). Representative examples of different enzyme classes are discussed, together with a critical vision of the limitations and discussing prospects of using DESs for biocatalysis. |
eng |
dc.language.iso |
eng |
|
dc.publisher |
Basel : MDPI |
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dc.relation.ispartofseries |
Catalysts 14 (2024), Nr. 1 |
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dc.rights |
CC BY 4.0 Unported |
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dc.rights.uri |
https://creativecommons.org/licenses/by/4.0 |
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dc.subject |
active pharmaceutical active ingredients |
eng |
dc.subject |
biocatalysis |
eng |
dc.subject |
deep eutectic solvents |
eng |
dc.subject |
enzymes |
eng |
dc.subject |
green chemistry |
eng |
dc.subject.ddc |
540 | Chemie
|
|
dc.title |
Biocatalysis for the Synthesis of Active Pharmaceutical Ingredients in Deep Eutectic Solvents: State-of-the-Art and Prospects |
eng |
dc.type |
Article |
|
dc.type |
Text |
|
dc.relation.essn |
2073-4344 |
|
dc.relation.doi |
https://doi.org/10.3390/catal14010084 |
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dc.bibliographicCitation.issue |
1 |
|
dc.bibliographicCitation.volume |
14 |
|
dc.bibliographicCitation.firstPage |
84 |
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dc.description.version |
publishedVersion |
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tib.accessRights |
frei zug�nglich |
|