dc.identifier.uri |
http://dx.doi.org/10.15488/16719 |
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dc.identifier.uri |
https://www.repo.uni-hannover.de/handle/123456789/16846 |
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dc.contributor.author |
Hoeper, Juliana Rachel
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dc.contributor.author |
Zeidler, Jan
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dc.contributor.author |
Meyer, Sara Eileen
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dc.contributor.author |
Gauler, Georg
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dc.contributor.author |
Steffens-Korbanka, Patricia
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dc.contributor.author |
Welcker, Martin
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dc.contributor.author |
Wendler, Jörg
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dc.contributor.author |
Schuch, Florian
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dc.contributor.author |
von Hinüber, Ulrich
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dc.contributor.author |
Schwarting, Andreas
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dc.contributor.author |
Witte, Torsten
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dc.contributor.author |
Meyer-Olson, Dirk
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dc.contributor.author |
Hoeper, Kirsten
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dc.date.accessioned |
2024-03-21T10:56:54Z |
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dc.date.available |
2024-03-21T10:56:54Z |
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dc.date.issued |
2021 |
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dc.identifier.citation |
Hoeper, J.R.; Zeidler, J.; Meyer, S.E.; Gauler, G.; Steffens-Korbanka, P. et al.: Effect of nurse-led care on outcomes in patients with ACPA/RF-positive rheumatoid arthritis with active disease undergoing treat-to-target: A multicentre randomised controlled trial. In: RMD Open 7 (2021), Nr. 1, e001627. DOI: https://doi.org/10.1136/rmdopen-2021-001627 |
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dc.description.abstract |
Objective To determine the non-inferiority of nurse-led care (NLC) in patients with anticitrullinated protein antibody (ACPA)-positive and/or rheumatoid factor (RF)-positive rheumatoid arthritis (RA) with active disease who are starting disease-modifying antirheumatic drug therapy, following treat-to-target (T2T) recommendations. Methods A multicentre, pragmatic randomised controlled trial was conducted to assess clinical effectiveness, anxiety, depression and patient satisfaction following a non-inferiority design. The participants were 224 adults with ACPA/RF-positive RA who were randomly assigned to either NLC or rheumatologist-led care (RLC). The primary outcome was the Disease Activity Score in 28 Joints measured with C reactive protein (DAS28-CRP) assessed at baseline and after 3, 6, 9 and 12 months. A DAS28-CRP difference of 0.6 was set as the non-inferiority margin. Mean differences between the groups were assessed following per-protocol and intention-to-treat strategies. Results Demographic data and baseline characteristics of patients in the NLC group (n=111) were comparable to those of patients in the RLC group (n=113). The improvement in disease activity (change in DAS28-CRP, primary outcome) over the course of 12 months was significant in both groups (p<0.001). No significant differences were observed between the NLC and RLC groups (p=0.317). Non-inferiority of NLC was shown for the primary outcome and all secondary outcomes. Conclusion This study supported the non-inferiority of NLC in managing T2T and follow-up care of patients with RA with moderate to high disease activity and poor prognostic factors in addition to RLC. Trial registration number DRKS00013055. |
eng |
dc.language.iso |
eng |
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dc.publisher |
London : BMJ Publishing Group |
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dc.relation.ispartofseries |
RMD Open 7 (2021), Nr. 1 |
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dc.rights |
CC BY-NC 4.0 Unported |
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dc.rights.uri |
https://creativecommons.org/licenses/by-nc/4.0/ |
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dc.subject |
health services research |
eng |
dc.subject |
nursing |
eng |
dc.subject |
outcomes research |
eng |
dc.subject |
rheumatoid arthritis |
eng |
dc.subject.ddc |
610 | Medizin, Gesundheit
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dc.title |
Effect of nurse-led care on outcomes in patients with ACPA/RF-positive rheumatoid arthritis with active disease undergoing treat-to-target: A multicentre randomised controlled trial |
eng |
dc.type |
Article |
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dc.type |
Text |
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dc.relation.essn |
2056-5933 |
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dc.relation.doi |
https://doi.org/10.1136/rmdopen-2021-001627 |
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dc.bibliographicCitation.issue |
1 |
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dc.bibliographicCitation.volume |
7 |
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dc.bibliographicCitation.firstPage |
e001627 |
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dc.description.version |
publishedVersion |
eng |
tib.accessRights |
frei zug�nglich |
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dc.bibliographicCitation.articleNumber |
e001627 |
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