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dc.identifier.uri Juerjens, Gerrit Kirschning, Andreas Candito, David A. 2015-12-08T13:08:05Z 2016-03-02T23:05:29Z 2015-03-02
dc.identifier.citation Juerjens, Gerrit; Kirschning, Andreas; Candito, David A.: Lessons from the Synthetic Chemist Nature. In: Natural Product Reports 32 (2015), Nr. 5, S. 723-737. DOI:
dc.description.abstract This conceptual review examines the ideal multistep synthesis from the perspective of nature. We suggest that besides step- and redox economies, one other key to efficiency is steady state processing with intermediates that are immediately transformed to the next intermediate when formed. We discuss four of nature's strategies (multicatalysis, domino reactions, iteration and compartmentation) that commonly proceed via short-lived intermediates and show that these strategies are also part of the chemist's portfolio. We particularly focus on compartmentation which in nature is found microscopically within cells (organelles) and between cells and on a molecular level on multiprotein scaffolds (e.g. in polyketide synthases) and demonstrate how compartmentation is manifested in modern multistep flow synthesis. eng
dc.language.iso eng eng
dc.publisher Cambridge : Royal Society of Chemistry
dc.relation.ispartofseries Natural Product Reports 32 (2015), Nr. 5
dc.rights Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
dc.subject asymmetric total-synthesis eng
dc.subject one-pot preparation eng
dc.subject organic-synthesis eng
dc.subject isotactic polymethoxy-1-alkenes eng
dc.subject enantioselective hydrogenation eng
dc.subject polyketide synthases eng
dc.subject product synthesis eng
dc.subject ideal synthesis eng
dc.subject step economy eng
dc.subject biosynthesis eng
dc.subject.ddc 540 | Chemie ger
dc.subject.ddc 570 | Biowissenschaften, Biologie ger
dc.title Lessons from the Synthetic Chemist Nature eng
dc.type article
dc.type Text
dc.relation.essn 1460-4752
dc.relation.issn 0265-0568
dc.bibliographicCitation.issue 5
dc.bibliographicCitation.volume 32
dc.bibliographicCitation.firstPage 723
dc.bibliographicCitation.lastPage 737
dc.description.version publishedVersion
tib.accessRights frei zug�nglich

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