Analysis and Design of Stimulus Response Curves of E. coli

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dc.identifier.uri Kremling, Andreas Goehler, Anna Jahreis, Knut Nees, Markus Auerbach, Benedikt Schmidt-Heck, Wolfgang Kokpinar, Oznur Geffers, Robert Rinas, Ursula Bettenbrock, Katja 2017-05-30T11:42:07Z 2017-05-30T11:42:07Z 2012
dc.identifier.citation Kremling, Andreas; Goehler, Anna; Jahreis, Knut; Nees, Markus; Auerbach, Benedikt et al.: Analysis and Design of Stimulus Response Curves of E. coli. In: Metabolites 2 (2012), Nr. 4, S. 844-871. DOI:
dc.description.abstract Metabolism and signalling are tightly coupled in bacteria. Combining several theoretical approaches, a core model is presented that describes transcriptional and allosteric control of glycolysis in Escherichia coli. Experimental data based on microarrays, signalling components and extracellular metabolites are used to estimate kinetic parameters. A newly designed strain was used that adjusts the incoming glucose flux into the system and allows a kinetic analysis. Based on the results, prediction for intracelluar metabolite concentrations over a broad range of the growth rate could be performed and compared with data from literature. eng
dc.language.iso eng
dc.publisher Basel : MDPI AG
dc.relation.ispartofseries Metabolites 2 (2012), Nr. 4
dc.rights CC BY 3.0 Unported
dc.subject carbohydrate uptake eng
dc.subject Escherichia coli eng
dc.subject feedforward control eng
dc.subject gene regulatory network eng
dc.subject network component analysis eng
dc.subject parameter estimation eng
dc.subject.ddc 570 | Biowissenschaften, Biologie ger
dc.title Analysis and Design of Stimulus Response Curves of E. coli eng
dc.type article
dc.type Text
dc.relation.issn 2218-1989
dc.bibliographicCitation.issue 4
dc.bibliographicCitation.volume 2
dc.bibliographicCitation.firstPage 844
dc.bibliographicCitation.lastPage 871
dc.description.version publishedVersion
tib.accessRights frei zug�nglich

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