Paleo-soraphens: chemical total syntheses and biological studies

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dc.identifier.uri Lu, Hai-Hua Hinkelmann, Bettina Tautz, Thomas Li, Jun Sasse, Florenz Franke, Raimo Kalesse, Markus 2015-12-08T13:08:04Z 2016-06-19T22:05:25Z 2015-06-19
dc.identifier.citation Lu, Hai-Hua; Hinkelmann, Bettina; Tautz, Thomas; Li, Jun; Sasse, Florenz; Franke, Raimo; Kalesse, Markus: Paleo-soraphens: chemical total syntheses and biological studies. In: Organic & Biomolecular Chemistry 13 (2015), Nr. 29, S. 8029-8036. DOI:
dc.description.abstract The soraphens are natural products that exhibit a molecular structure different from what would have been expected by following its polyketidal assembly line. The most significant differences are the presence of a hemiketal instead of a trisubstituted double bond and a double bond at C9 and C10 where a saturated carbon chain was expected. We were interested in the biological activity of the soraphens with architectures as described by the polyketide synthase since we hypothesized that these modifications reflect the evolutionary optimization of the soraphens. Herein we describe four additional derivatives of the so-called paleo-soraphens and their biological profiling to provide a picture of the hypothetical evolutionary optimization of this family of natural products. The syntheses required a unified and convergent strategy and their biological profiling was performed with the aid of impedance measurements. The results of these biological experiments are consistent with the proposed evolutionary optimization of the soraphens. eng
dc.language.iso eng eng
dc.publisher Cambridge : Royal Society of Chemistry
dc.relation.ispartofseries Organic & Biomolecular Chemistry 13 (2015), Nr. 29
dc.rights Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
dc.subject fatty-acid synthesis eng
dc.subject sorangium-cellulosum eng
dc.subject gene-cluster eng
dc.subject stereochemical determination eng
dc.subject structure elucidation eng
dc.subject inhibitor eng
dc.subject biosynthesis eng
dc.subject convergent eng
dc.subject alkylation eng
dc.subject.ddc 540 | Chemie ger
dc.title Paleo-soraphens: chemical total syntheses and biological studies eng
dc.type article
dc.type Text
dc.relation.essn 1477-0539
dc.relation.issn 1477-0520
dc.bibliographicCitation.issue 29
dc.bibliographicCitation.volume 13
dc.bibliographicCitation.firstPage 8029
dc.bibliographicCitation.lastPage 8036
dc.description.version publishedVersion
tib.accessRights frei zug�nglich

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