JavaScript is disabled for your browser. Some features of this site may not work without it.
Originalpublikation
Linne, Y.; Bonandi, E.; Tabet, C.; Geldsetzer, J.; Kalesse, M.: The Total Synthesis of Chondrochloren A. In: Angewandte Chemie International Edition 60 (2021), Nr. 13, S. 6938-6942. DOI: https://doi.org/10.1002/anie.202016072
The first total synthesis of chondrochloren A is accomplished using a 1,2-metallate rearrangement addition as an alternative for the Nozaki-Hiyama-Kishi reaction. This transformation also avoids the inherent challenges of this polyketide segment and provides a new, unprecedented strategy to assemble polyketidal frameworks. The formation of the Z-enamide is accomplished using a Z-selective cross coupling of the corresponding amide to a Z-vinyl bromide.