dc.identifier.uri |
http://dx.doi.org/10.15488/13350 |
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dc.identifier.uri |
https://www.repo.uni-hannover.de/handle/123456789/13459 |
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dc.contributor.author |
Koeder, Christian
|
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dc.contributor.author |
Anand, Corinna
|
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dc.contributor.author |
Husain, Sarah
|
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dc.contributor.author |
Kranz, Ragna-Marie
|
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dc.contributor.author |
Schoch, Nora
|
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dc.contributor.author |
Alzughayyar, Dima
|
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dc.contributor.author |
Bitterlich, Norman
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dc.contributor.author |
Hahn, Andreas
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dc.contributor.author |
Englert, Heike
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dc.date.accessioned |
2023-03-21T06:08:05Z |
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dc.date.available |
2023-03-21T06:08:05Z |
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dc.date.issued |
2023 |
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dc.identifier.citation |
Koeder, C.; Anand, C.; Husain, S.; Kranz, R.-M.; Schoch, N. et al.: Exploratory analysis of the effect of a controlled lifestyle intervention on inflammatory markers – the Healthy Lifestyle Community Programme (cohort 2). In: BMC nutrition 9 (2023), 25. DOI: https://doi.org/10.1186/s40795-023-00684-2 |
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dc.description.abstract |
Background: Chronic low-grade inflammation is associated with an increased risk of chronic disease and mortality. The objective of the study was to test the effect of a healthy lifestyle intervention on biomarkers of inflammation (among other risk markers). Methods: We conducted a non-randomized controlled trial with mostly middle-aged and elderly participants from the general population in rural northwest Germany (intervention: n = 114; control: n = 87). The intervention consisted of a 1-year lifestyle programme focusing on diet (largely plant-based; strongest emphasis), physical activity, stress management, and social support. High-sensitivity C-reactive protein (hs-CRP) was assessed at baseline, 10 weeks, 6 months, and 1 year. Homocysteine (Hcy) was assessed at baseline, 10 weeks, and 1 year. Adiponectin (Apn) was assessed at baseline and 10 weeks. An exploratory analysis of these inflammatory markers assessing the between-group differences with ANCOVA was conducted. Results: The 1-year trajectory of hs-CRP was significantly lower in the intervention group compared to control (between-group difference: -0.8 (95% CI -1.2, -0.3) mg/l; p = 0.001; adjusted for baseline). The 1-year trajectory of Hcy was non-significantly higher in the intervention compared to control (between-group difference: 0.2 (95% CI -0.3, 0.7) µmol/l; p = 0.439; adjusted for baseline). From baseline to 10 weeks, Apn decreased significantly more in the intervention group compared to control (between-group difference: -1.6 (95% CI -2.7, -0.5) µg/ml; p = 0.004; adjusted for baseline). Conclusions: Our study shows that healthy lifestyle changes can lower hs-CRP and Apn levels and are unlikely to significantly affect Hcy levels within 1 year. Trial registration: German Clinical Trials Register (DRKS; reference: DRKS00018775, registered 12 Sept 2019; retrospectively registered; www.drks.de). |
eng |
dc.language.iso |
eng |
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dc.publisher |
London : BioMed Central |
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dc.relation.ispartofseries |
BMC nutrition 9 (2023) |
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dc.rights |
CC BY 4.0 Unported |
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dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
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dc.subject |
Adiponectin |
eng |
dc.subject |
C-reactive protein |
eng |
dc.subject |
Cardiovascular disease |
eng |
dc.subject |
Homocysteine |
eng |
dc.subject |
Lifestyle intervention |
eng |
dc.subject |
Plant-based diet |
eng |
dc.subject |
Subclinical inflammation |
eng |
dc.subject.ddc |
610 | Medizin, Gesundheit
|
ger |
dc.title |
Exploratory analysis of the effect of a controlled lifestyle intervention on inflammatory markers – the Healthy Lifestyle Community Programme (cohort 2) |
|
dc.type |
Article |
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dc.type |
Text |
|
dc.relation.essn |
2055-0928 |
|
dc.relation.doi |
https://doi.org/10.1186/s40795-023-00684-2 |
|
dc.bibliographicCitation.volume |
9 |
|
dc.bibliographicCitation.firstPage |
25 |
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dc.description.version |
publishedVersion |
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tib.accessRights |
frei zug�nglich |
|