Development of Phytocosmeceutical Microemulgel Containing Flaxseed Extract and Its In Vitro and In Vivo Characterization

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dc.identifier.uri Tasneem, Rabia Khan, Haji Muhammad Shoaib Rasool, Fatima Khan, Kashif-ur-Rehman Umair, Muhammad Esatbeyoglu, Tuba Korma, Sameh A. 2022-09-08T12:03:16Z 2022-09-08T12:03:16Z 2022
dc.identifier.citation Tasneem, R.; Khan, H.M.S.; Rasool, F.; Khan, K.-u.-R.; Umair, M. et al.: Development of Phytocosmeceutical Microemulgel Containing Flaxseed Extract and Its In Vitro and In Vivo Characterization. In: Pharmaceutics 14 (2022), Nr. 8, 1656. DOI:
dc.description.abstract Antioxidants from natural sources are extensively attaining consideration to avert the skin from damage and aging caused by free radicals. Flaxseed (Linum usitatissimum L.), a natural therapeutic agent, was meant to be explored cosmeceutical by quantifying its potential phytoconstituents and to be incorporated into a microemulgel for topical use. Hydroalcoholic fractions (both methanolic and ethanolic; 80%) flaxseed extracts were subjected to phytochemical screening by quantifying total phenolic content (TPC), total flavonoid content (TFC), and high-performance liquid chromatography-ultraviolet (HPLC-UV), and for biological activities through 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, tyrosinase inhibition assay, and sun protection factor (SPF). Ethanolic fraction was selected for further study by TPC (18.75 mg gallic acid equivalent/g) and TFC (1.34 mg quercetin equivalent/g). HPLC-UV analysis showed the existence of benzoic, quercetin, caffeic, vanillic, p-coumaric, gallic, cinnamic, syringic, and sinapic acids. Biological activities showed 87.00%, 72.00%, and 21.75 values for DPPH assay, tyrosinase inhibition, and SPF assays, respectively. An oil-in-water (OW) microemulsion containing the flaxseed extract, with 99.20 nm Zeta size, −19.3 Zeta potential and 0.434 polydispersity index was developed and incorporated in Carbopol-940 gel matrix to formulate an active microemulgel with 59.15% release in in vitro studies. The successfully formulated stable active microemulgel produced statistically significant effects (p < 0.05), in comparison to a placebo, on skin erythema, melanin, sebum, moisture, and elasticity, in a noninvasive in vivo study performed on 13 healthy human female volunteers. Other cosmeceutical products can also be formulated from flaxseed, making it a considerable candidate for further utilization in the pharmaceutical industry. eng
dc.language.iso eng
dc.publisher Basel : MDPI
dc.relation.ispartofseries Pharmaceutics 14 (2022), Nr. 8
dc.rights CC BY 4.0 Unported
dc.subject antioxidant eng
dc.subject cosmetic eng
dc.subject formulation development eng
dc.subject HPLC-UV eng
dc.subject in vivo study eng
dc.subject Linum usitatissimum eng
dc.subject pharmaceutic eng
dc.subject topical eng
dc.subject phytocosmetics eng
dc.subject radical scavenging activity eng
dc.subject.ddc 610 | Medizin, Gesundheit ger
dc.title Development of Phytocosmeceutical Microemulgel Containing Flaxseed Extract and Its In Vitro and In Vivo Characterization
dc.type Article
dc.type Text
dc.relation.essn 1999-4923
dc.bibliographicCitation.issue 8
dc.bibliographicCitation.volume 14
dc.bibliographicCitation.firstPage 1656
dc.description.version publishedVersion
tib.accessRights frei zug�nglich

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