dc.identifier.uri |
http://dx.doi.org/10.15488/12398 |
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dc.identifier.uri |
https://www.repo.uni-hannover.de/handle/123456789/12497 |
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dc.contributor.author |
Rodriguez-Niño, Angelica
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dc.contributor.author |
Pastene, Diego O.
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dc.contributor.author |
Post, Adrian
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dc.contributor.author |
Yusof Said, M.
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dc.contributor.author |
Gomes-Neto, Antonio W.
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dc.contributor.author |
Kieneker, Lyanne M.
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dc.contributor.author |
Heiner-Fokkema, M. Rebecca
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dc.contributor.author |
Esatbeyoglu, Tuba
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dc.contributor.author |
Rimbach, Gerald
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dc.contributor.author |
Schnuelle, Peter
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dc.contributor.author |
Yard, Benito A.
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dc.contributor.author |
Bakker, Stephan J. L.
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dc.date.accessioned |
2022-07-04T05:03:55Z |
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dc.date.available |
2022-07-04T05:03:55Z |
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dc.date.issued |
2021 |
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dc.identifier.citation |
Rodriguez-Niño, A.; Pastene, D.O.; Post, A.; Yusof Said, M.; Gomes-Neto, A.W. et al.: Urinary carnosinase-1 excretion is associated with urinary carnosine depletion and risk of graft failure in kidney transplant recipients: Results of the transplantlines cohort study. In: Antioxidants 10 (2021), Nr. 7, 1102. DOI: https://doi.org/10.3390/antiox10071102 |
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dc.description.abstract |
Carnosine affords protection against oxidative and carbonyl stress, yet high concentrations of the carnosinase-1 enzyme may limit this. We recently reported that high urinary carnosi-nase-1 is associated with kidney function decline and albuminuria in patients with chronic kidney disease. We prospectively investigated whether urinary carnosinase-1 is associated with a high risk for development of late graft failure in kidney transplant recipients (KTRs). Carnosine and carnosi-nase-1 were measured in 24 h urine in a longitudinal cohort of 703 stable KTRs and 257 healthy controls. Cox regression was used to analyze the prospective data. Urinary carnosine excretions were significantly decreased in KTRs (26.5 [IQR 21.4–33.3] µmol/24 h versus 34.8 [IQR 25.6–46.8] µmol/24 h; p < 0.001). In KTRs, high urinary carnosinase-1 concentrations were associated with increased risk of undetectable urinary carnosine (OR 1.24, 95%CI [1.06–1.45]; p = 0.007). During median follow-up for 5.3 [4.5–6.0] years, 84 (12%) KTRs developed graft failure. In Cox regression analyses, high urinary carnosinase-1 excretions were associated with increased risk of graft failure (HR 1.73, 95%CI [1.44–2.08]; p < 0.001) independent of potential confounders. Since urinary carnosine is depleted and urinary carnosinase-1 imparts a higher risk for graft failure in KTRs, future studies determining the potential of carnosine supplementation in these patients are warranted. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
eng |
dc.language.iso |
eng |
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dc.publisher |
Basel : MDPI AG |
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dc.relation.ispartofseries |
Antioxidants 10 (2021), Nr. 7 |
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dc.rights |
CC BY 4.0 Unported |
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dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
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dc.subject |
Carnosinase-1 |
eng |
dc.subject |
Carnosine |
eng |
dc.subject |
Graft failure |
eng |
dc.subject |
Kidney transplantation |
eng |
dc.subject |
Oxidative stress |
eng |
dc.subject.ddc |
540 | Chemie
|
ger |
dc.subject.ddc |
610 | Medizin, Gesundheit
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ger |
dc.title |
Urinary carnosinase-1 excretion is associated with urinary carnosine depletion and risk of graft failure in kidney transplant recipients: Results of the transplantlines cohort study |
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dc.type |
Article |
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dc.type |
Text |
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dc.relation.essn |
2076-3921 |
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dc.relation.doi |
https://doi.org/10.3390/antiox10071102 |
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dc.bibliographicCitation.issue |
7 |
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dc.bibliographicCitation.volume |
10 |
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dc.bibliographicCitation.firstPage |
1102 |
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dc.description.version |
publishedVersion |
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tib.accessRights |
frei zug�nglich |
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