Abstract: | |
The development of multifunctional nanoscale systems that can mediate efficient tumor targeting, together with high cellular internalization, is crucial for the diagnosis of glioma. The combination of imaging agents into one platform provides dual imaging and allows further surface modification with targeting ligands for specific glioma detection. Herein, transferrin (Tf)-decorated niosomes with integrated magnetic iron oxide nanoparticles (MIONs) and quantum dots (QDs) were formulated (PEGNIO/QDs/MIONs/Tf) for efficient imaging of glioma, supported by magnetic and active targeting. Transmission electron microscopy confirmed the complete co-encapsulation of MIONs and QDs in the niosomes. Flow cytometry analysis demonstrated enhanced cellular uptake of the niosomal formulation by glioma cells. In vitro imaging studies showed that PEG-NIO/QDs/MIONs/Tf produces an obvious negative-contrast enhancement effect on glioma cells by magnetic resonance imaging (MRI) and also improved fluorescence intensity under fluorescence microscopy. This novel platform represents the first niosome-based system which combines magnetic nanoparticles and QDs, and has application potential in dual-targeted imaging of glioma. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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License of this version: | CC BY 4.0 Unported - https://creativecommons.org/licenses/by/4.0/ |
Publication type: | Article |
Publishing status: | publishedVersion |
Publication date: | 2021 |
Keywords english: | Glioma imaging, Iron oxide nanoparticles, Multifunctional niosomes, Quantum dots, indium, indium phosphide, magnetic iron oxide nanoparticle, magnetic nanoparticle, niosome, quantum dot, transferrin, unclassified drug, zinc sulfide, contrast medium, ferric ion, ferric oxide, liposome, macrogol, nanoparticle, quantum dot, transferrin, Article, contrast enhancement, controlled study, drug formulation, flow cytometry, fluorescence intensity, fluorescence microscopy, glioma, glioma cell, human, human cell, in vitro study, nanoencapsulation, neuroimaging, nuclear magnetic resonance imaging, transmission electron microscopy, animal, chemistry, diagnostic imaging, genetics, glioma, magnetism, metabolism, procedures, tumor cell line, Animals, Cell Line, Tumor, Contrast Media, Ferric Compounds, Glioma, Humans, Liposomes, Magnetic Iron Oxide Nanoparticles, Magnetic Resonance Imaging, Magnetics, Microscopy, Electron, Transmission, Nanoparticles, Polyethylene Glycols, Quantum Dots, Transferrin |
DDC: | 570 | Biowissenschaften, Biologie, 540 | Chemie |
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