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Originalpublikation
Kudelin, A.I.; Papathanasiou, K.; Isaeva, V.; Caro, J.; Salmi, T. et al.: Microwave-assisted synthesis, characterization and modeling of cpo-27-mg metal-organic framework for drug delivery. In: Molecules 26 (2021), Nr. 2, 426. DOI: https://doi.org/10.3390/molecules26020426
Version im Repositorium
Zum Zitieren der Version im Repositorium verwenden Sie bitte diesen DOI:
https://doi.org/10.15488/12306
| Zusammenfassung: | |
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The coordination polymer CPO-27-Mg was rapidly synthesized under microwave irra-diation. This material exhibits a sufficiently high drug loading towards aspirin (~8% wt.) and paracetamol (~14% wt.). The binding of these two molecules with the inner surface of the metal-organic framework was studied employing the Gaussian and Plane Wave approach of the Density Functional Theory. The structure of CPO-27-Mg persists after the adsorption of aspirin or paracetamol and their desorption energies, being quite high, decrease under solvent conditions. © 2021 by the authors. Li-censee MDPI, Basel, Switzerland.
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| Lizenzbestimmungen: | CC BY 4.0 Unported - https://creativecommons.org/licenses/by/4.0/ |
| Publikationstyp: | Article |
| Publikationsstatus: | publishedVersion |
| Erstveröffentlichung: | 2021 |
| Schlagwörter (englisch): | Aspirin, CPO-27, Drug delivery, Metal-organic frameworks, Microwave synthesis, Paracetamol, acetylsalicylic acid, analgesic agent, drug carrier, metal organic framework, nonsteroid antiinflammatory agent, organometallic compound, paracetamol, drug delivery system, microwave radiation, procedures, synthesis, Acetaminophen, Analgesics, Non-Narcotic, Anti-Inflammatory Agents, Non-Steroidal, Aspirin, Drug Carriers, Drug Delivery Systems, Metal-Organic Frameworks, Microwaves, Organometallic Compounds |
| Fachliche Zuordnung (DDC): | 540 | Chemie |
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