dc.identifier.uri |
http://dx.doi.org/10.15488/12257 |
|
dc.identifier.uri |
https://www.repo.uni-hannover.de/handle/123456789/12355 |
|
dc.contributor.author |
Afifi, Sherif M.
|
|
dc.contributor.author |
Ammar, Naglaa M.
|
|
dc.contributor.author |
Kamel, Rabab
|
|
dc.contributor.author |
Esatbeyoglu, Tuba
|
|
dc.contributor.author |
Hassan, Heba A.
|
|
dc.date.accessioned |
2022-06-15T10:10:26Z |
|
dc.date.available |
2022-06-15T10:10:26Z |
|
dc.date.issued |
2022 |
|
dc.identifier.citation |
Afifi, S.M.; Ammar, N.M.; Kamel, R.; Esatbeyoglu, T.; Hassan, H.A.: β-Sitosterol Glucoside-Loaded Nanosystem Ameliorates Insulin Resistance and Oxidative Stress in Streptozotocin-Induced Diabetic Rats. In: Antioxidants : open access journal 11 (2022), Nr. 5, 1023. DOI: https://doi.org/10.3390/antiox11051023 |
|
dc.description.abstract |
β-Sitosterol glucoside (SG), isolated from Senecio petasitis (Family Asteraceae), was loaded in self-nanoemulsifying drug delivery systems (SEDDS) in a trial to enhance its solubility and biological effect. Various co-surfactants were tested to prepare a successful SEDDS. The selected SG-loaded SEDDS had a droplet size of 134 ± 15.2 nm with a homogenous distribution (polydispersity index 0.296 ± 0.02). It also demonstrated a significant augmentation of SG in vitro release by 4-fold compared to the free drug suspension. The in vivo insulin sensitivity and antidiabetic effect of the prepared SG-loaded SEDDS were further assessed in streptozotocin-induced hyperglycemic rats. The hypoglycemic effect of SG-loaded nanosystem was evidenced by decreased serum glucose and insulin by 63.22% and 53.11%, respectively. Homeostasis model assessment-insulin resistance (HOMA-IR) index demonstrated a significant reduction by 5.4-fold in the diabetic group treated by SG-loaded nanosystem and exhibited reduced glucagon level by 40.85%. In addition, treatment with SG-loaded nanosystem significantly decreased serum MDA (malondialdehyde) and increased catalase levels by 38.31% and 64.45%, respectively. Histopathological investigations also supported the protective effect of SG-loaded nanosystem on the pancreas. The promising ability of SG-loaded nanosystem to ameliorate insulin resistance, protect against oxidative stress, and restore pancreatic β-cell secretory function warrants its inclusion in further studies during diabetes progression. |
eng |
dc.language.iso |
eng |
|
dc.publisher |
Basel : MDPI |
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dc.relation.ispartofseries |
Antioxidants : open access journal 11 (2022), Nr. 5 |
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dc.rights |
CC BY 4.0 Unported |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
antidiabetic |
eng |
dc.subject |
glucagon |
eng |
dc.subject |
insulin resistance |
eng |
dc.subject |
malondialdehyde |
eng |
dc.subject |
nanoemulsion |
eng |
dc.subject |
oxidative stress |
eng |
dc.subject |
release study |
eng |
dc.subject |
SEDDS |
eng |
dc.subject |
Senecio petasitis |
eng |
dc.subject.ddc |
540 | Chemie
|
ger |
dc.subject.ddc |
610 | Medizin, Gesundheit
|
ger |
dc.title |
β-Sitosterol Glucoside-Loaded Nanosystem Ameliorates Insulin Resistance and Oxidative Stress in Streptozotocin-Induced Diabetic Rats |
|
dc.type |
Article |
|
dc.type |
Text |
|
dc.relation.essn |
2076-3921 |
|
dc.relation.doi |
https://doi.org/10.3390/antiox11051023 |
|
dc.bibliographicCitation.issue |
5 |
|
dc.bibliographicCitation.volume |
11 |
|
dc.bibliographicCitation.firstPage |
1023 |
|
dc.description.version |
publishedVersion |
|
tib.accessRights |
frei zug�nglich |
|