dc.identifier.uri |
http://dx.doi.org/10.15488/12234 |
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dc.identifier.uri |
https://www.repo.uni-hannover.de/handle/123456789/12332 |
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dc.contributor.author |
Jonczyk, Rebecca
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dc.contributor.author |
Stanislawski, Nils
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dc.contributor.author |
Seiler, Lisa K.
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dc.contributor.author |
Blume, Holger
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dc.contributor.author |
Heiden, Stefanie
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dc.contributor.author |
Lucas, Henning
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dc.contributor.author |
Sarikouch, Samir
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dc.contributor.author |
Pott, Philipp-Cornelius
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dc.contributor.author |
Stiesch, Meike
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dc.contributor.author |
Hauß, Corinna
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dc.contributor.author |
Saletti, Giulietta
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dc.contributor.author |
González-Hernández, Mariana
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dc.contributor.author |
Kaiser, Franziska Karola
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dc.contributor.author |
Rimmelzwaan, Guus
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dc.contributor.author |
Osterhaus, Albert
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dc.contributor.author |
Blume, Cornelia
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dc.date.accessioned |
2022-06-15T05:27:03Z |
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dc.date.available |
2022-06-15T05:27:03Z |
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dc.date.issued |
2022 |
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dc.identifier.citation |
Jonczyk, R.; Stanislawski, N.; Seiler, L.K.; Blume, H.; Heiden, S. et al.: Combined Prospective Seroconversion and PCR Data of Selected Cohorts Indicate a High Rate of Subclinical SARS-CoV-2 Infections—an Open Observational Study in Lower Saxony, Germany. In: Microbiology spectrum 10 (2022), Nr. 1, e01512-21. DOI: https://doi.org/10.1128/spectrum.01512-21 |
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dc.description.abstract |
Despite lockdown measures, intense symptom-based PCR, and antigen testing, the SARS-CoV-2 pandemic spread further. In this open observational study conducted in Lower Saxony, Germany, voluntary SARS-CoV-2 PCR tests were performed from April 2020 until June 2021, supported by serum antibody testing to prove whether PCR testing in subjects with none or few symptoms of COVID-19 is a suitable tool to manage the pandemic. In different mobile stations, 4,817 subjects from three different working fields participated in the PCR testing. Serum antibody screening using the SARS-CoV-2 ViraChip IgG (Viramed, Germany) and the Elecsys Anti-SARS-CoV-2 assay (Roche, Germany) was performed alongside virus neutralization testing. Subjects were questioned regarding comorbidities and COVID-19 symptoms. Fifty-one subjects with acute SARS-CoV-2 infection were detected of which 31 subjects did not show any symptoms possibly characteristic for COVID-19. An additional 37 subjects reported a previous SARS-CoV-2 infection (total prevalence 1.82%). Seroconversion was discovered in 58 subjects with known SARS-CoV-2 infection and in 58 subjects that never had a positive PCR test. The latter had a significantly lower Charlson Comorbidity Index, and one third of them were asymptomatic. In 50% of all seroconverted subjects, neutralizing serum antibodies (NAbs) were detectable in parallel to N/S1 (n = 16) or N/S1/S2 antigen specific antibodies (n = 40) against SARS-CoV-2. NAb titers decreased within 100 days after PCR-confirmed SARS-CoV-2 acute infection by at least 2.5-fold. A relatively high rate of subclinical SARS-CoV-2 infections may contribute to the spread of SARS-CoV-2, suggesting that in addition to other intervention strategies, systematic screening of asymptomatic persons by PCR testing may significantly enable better pandemic control. |
eng |
dc.language.iso |
eng |
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dc.publisher |
Birmingham, Ala. : ASM |
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dc.relation.ispartofseries |
Microbiology spectrum 10 (2022), Nr. 1 |
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dc.rights |
CC BY 4.0 Unported |
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dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
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dc.subject |
COVID-19 |
eng |
dc.subject |
subclinical cases |
eng |
dc.subject |
PCR |
eng |
dc.subject |
SARS-CoV-2 antibody screening |
eng |
dc.subject |
neutralizing antibodies |
eng |
dc.subject |
antibody screening tests |
eng |
dc.subject |
working groups |
eng |
dc.subject.ddc |
570 | Biowissenschaften, Biologie
|
ger |
dc.title |
Combined Prospective Seroconversion and PCR Data of Selected Cohorts Indicate a High Rate of Subclinical SARS-CoV-2 Infections—an Open Observational Study in Lower Saxony, Germany |
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dc.type |
Article |
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dc.type |
Text |
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dc.relation.essn |
2165-0497 |
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dc.relation.doi |
https://doi.org/10.1128/spectrum.01512-21 |
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dc.bibliographicCitation.issue |
1 |
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dc.bibliographicCitation.volume |
10 |
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dc.bibliographicCitation.firstPage |
e01512-21 |
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dc.description.version |
publishedVersion |
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tib.accessRights |
frei zug�nglich |
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