dc.identifier.uri |
http://dx.doi.org/10.15488/1183 |
|
dc.identifier.uri |
http://www.repo.uni-hannover.de/handle/123456789/1207 |
|
dc.contributor.author |
Huehnerschulte, Tim Andreas
|
|
dc.contributor.author |
Reifenrath, Janin
|
|
dc.contributor.author |
Rechenberg, Brigitte von
|
|
dc.contributor.author |
Dziuba, Dina
|
|
dc.contributor.author |
Seitz, Jan-Marten
|
|
dc.contributor.author |
Bormann, Dirk
|
|
dc.contributor.author |
Windhagen, Henning
|
|
dc.contributor.author |
Meyer-Lindenberg, Andrea
|
|
dc.date.accessioned |
2017-03-02T12:48:04Z |
|
dc.date.available |
2017-03-02T12:48:04Z |
|
dc.date.issued |
2012 |
|
dc.identifier.citation |
Huehnerschulte, Tim Andreas; Reifenrath, Janin; von Rechenberg, Brigitte; Dziuba, Dina; Seitz, Jan Marten et al.: In vivo assessment of the host reactions to the biodegradation of the two novel magnesium alloys ZEK100 and AX30 in an animal model. In: Biomedical Engineering Online 11 (2012), 14. DOI: https://doi.org/10.1186/1475-925X-11-14 |
|
dc.description.abstract |
Background: Most studies on biodegradable magnesium implants published recently use magnesium-calcium-alloys or magnesium-aluminum-rare earth-alloys. However, since rare earths are a mixture of elements and their toxicity is unclear, a reduced content of rare earths is favorable. The present study assesses the in vivo biocompatibility of two new magnesium alloys which have a reduced content (ZEK100) or contain no rare earths at all (AX30). Methods: 24 rabbits were randomized into 4 groups (AX30 or ZEK100, 3 or 6 months, respectively) and cylindrical pins were inserted in their tibiae. To assess the biodegradation μCT scans and histological examinations were performed. Results: The μCT scans showed that until month three ZEK100 degrades faster than AX30, but this difference is leveled out after 6 months. Histology revealed that both materials induce adverse host reactions and high numbers of osteoclasts in the recipient bone. The mineral apposition rates of both materials groups were high. Conclusions: Both alloys display favorable degradation characteristics, but they induce adverse host reactions, namely an osteoclast-driven resorption of bone and a subsequent periosteal formation of new bone. Therefore, the biocompatibility of ZEK100 and AX30 is questionable and further studies, which should focus on the interactions on cellular level, are needed. |
eng |
dc.description.sponsorship |
DFG/CRC/SFB599 |
|
dc.language.iso |
eng |
|
dc.publisher |
London : BioMed Central Ltd |
|
dc.relation.ispartofseries |
Biomedical Engineering Online 11 (2012) |
|
dc.rights |
CC BY 2.0 Unported |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/2.0/ |
|
dc.subject |
Magnesium |
eng |
dc.subject |
In vivo |
eng |
dc.subject |
Biocompatibility |
eng |
dc.subject |
Degradation |
eng |
dc.subject |
mu?-computed tomography |
eng |
dc.subject |
Histology |
eng |
dc.subject |
months implantation duration |
eng |
dc.subject |
mechanical-properties |
eng |
dc.subject |
rabbit model |
eng |
dc.subject |
extracellular calcium |
eng |
dc.subject |
orthopedic implants |
eng |
dc.subject |
resorbable implants |
eng |
dc.subject |
corrosion behavior |
eng |
dc.subject |
emerging insights |
eng |
dc.subject |
bone-resorption |
eng |
dc.subject |
vitro corrosion |
eng |
dc.subject.ddc |
610 | Medizin, Gesundheit
|
ger |
dc.title |
In vivo assessment of the host reactions to the biodegradation of the two novel magnesium alloys ZEK100 and AX30 in an animal model |
|
dc.type |
Article |
|
dc.type |
Text |
|
dc.relation.issn |
1475-925X |
|
dc.relation.doi |
https://doi.org/10.1186/1475-925X-11-14 |
|
dc.bibliographicCitation.volume |
11 |
|
dc.bibliographicCitation.firstPage |
14 |
|
dc.description.version |
publishedVersion |
|
tib.accessRights |
frei zug�nglich |
|