In vivo assessment of the host reactions to the biodegradation of the two novel magnesium alloys ZEK100 and AX30 in an animal model

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dc.identifier.uri http://dx.doi.org/10.15488/1183
dc.identifier.uri http://www.repo.uni-hannover.de/handle/123456789/1207
dc.contributor.author Huehnerschulte, Tim Andreas
dc.contributor.author Reifenrath, Janin
dc.contributor.author Rechenberg, Brigitte von
dc.contributor.author Dziuba, Dina
dc.contributor.author Seitz, Jan-Marten
dc.contributor.author Bormann, Dirk
dc.contributor.author Windhagen, Henning
dc.contributor.author Meyer-Lindenberg, Andrea
dc.date.accessioned 2017-03-02T12:48:04Z
dc.date.available 2017-03-02T12:48:04Z
dc.date.issued 2012
dc.identifier.citation Huehnerschulte, Tim Andreas; Reifenrath, Janin; von Rechenberg, Brigitte; Dziuba, Dina; Seitz, Jan Marten et al.: In vivo assessment of the host reactions to the biodegradation of the two novel magnesium alloys ZEK100 and AX30 in an animal model. In: Biomedical Engineering Online 11 (2012), 14. DOI: https://doi.org/10.1186/1475-925X-11-14
dc.description.abstract Background: Most studies on biodegradable magnesium implants published recently use magnesium-calcium-alloys or magnesium-aluminum-rare earth-alloys. However, since rare earths are a mixture of elements and their toxicity is unclear, a reduced content of rare earths is favorable. The present study assesses the in vivo biocompatibility of two new magnesium alloys which have a reduced content (ZEK100) or contain no rare earths at all (AX30). Methods: 24 rabbits were randomized into 4 groups (AX30 or ZEK100, 3 or 6 months, respectively) and cylindrical pins were inserted in their tibiae. To assess the biodegradation μCT scans and histological examinations were performed. Results: The μCT scans showed that until month three ZEK100 degrades faster than AX30, but this difference is leveled out after 6 months. Histology revealed that both materials induce adverse host reactions and high numbers of osteoclasts in the recipient bone. The mineral apposition rates of both materials groups were high. Conclusions: Both alloys display favorable degradation characteristics, but they induce adverse host reactions, namely an osteoclast-driven resorption of bone and a subsequent periosteal formation of new bone. Therefore, the biocompatibility of ZEK100 and AX30 is questionable and further studies, which should focus on the interactions on cellular level, are needed. eng
dc.description.sponsorship DFG/CRC/SFB599
dc.language.iso eng
dc.publisher London : BioMed Central Ltd
dc.relation.ispartofseries Biomedical Engineering Online 11 (2012)
dc.rights CC BY 2.0
dc.rights.uri https://creativecommons.org/licenses/by/2.0/
dc.subject Magnesium eng
dc.subject In vivo eng
dc.subject Biocompatibility eng
dc.subject Degradation eng
dc.subject mu?-computed tomography eng
dc.subject Histology eng
dc.subject months implantation duration eng
dc.subject mechanical-properties eng
dc.subject rabbit model eng
dc.subject extracellular calcium eng
dc.subject orthopedic implants eng
dc.subject resorbable implants eng
dc.subject corrosion behavior eng
dc.subject emerging insights eng
dc.subject bone-resorption eng
dc.subject vitro corrosion eng
dc.subject.ddc 610 | Medizin, Gesundheit ger
dc.title In vivo assessment of the host reactions to the biodegradation of the two novel magnesium alloys ZEK100 and AX30 in an animal model
dc.type Text
dc.type article
dc.relation.issn 1475-925X
dc.relation.doi https://doi.org/10.1186/1475-925X-11-14
dc.bibliographicCitation.volume 11
dc.bibliographicCitation.firstPage 14
dc.description.version publishedVersion
tib.accessRights frei zug�nglich


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