dc.identifier.uri |
http://dx.doi.org/10.15488/11654 |
|
dc.identifier.uri |
https://www.repo.uni-hannover.de/handle/123456789/11747 |
|
dc.contributor.author |
Senkler, Jennifer
|
eng |
dc.contributor.author |
Senkler, Michael
|
eng |
dc.contributor.author |
Braun, Hans-Peter
|
eng |
dc.date.accessioned |
2022-01-11T13:13:32Z |
|
dc.date.available |
2022-01-11T13:13:32Z |
|
dc.date.issued |
2017 |
eng |
dc.identifier.citation |
Senkler, J.; Senkler, M.; Braun, H.-P.: Structure and function of complex I in animals and plants – a comparative view. In: Physiologia Plantarum 161 (2017), Nr. 1, S. 6-15. DOI: https://doi.org/10.1111/ppl.12561 |
eng |
dc.description.abstract |
The mitochondrial NADH dehydrogenase complex (complex I) has a molecular mass of about 1000 kDa and includes 40–50 subunits in animals, fungi and plants. It is composed of a membrane arm and a peripheral arm and has a conserved L-like shape in all species investigated. However, in plants and possibly some protists it has a second peripheral domain which is attached to the membrane arm on its matrix exposed side at a central position. The extra domain includes proteins resembling prokaryotic gamma-type carbonic anhydrases. We here present a detailed comparison of complex I from mammals and flowering plants. Forty homologous subunits are present in complex I of both groups of species. In addition, five subunits are present in mammalian complex I, which are absent in plants, and eight to nine subunits are present in plant complex I which do not occur in mammals. Based on the atomic structure of mammalian complex I and biochemical insights into complex I architecture from plants we mapped the species-specific subunits. Interestingly, four of the five animal-specific and five of the eight to nine plant-specific subunits are localized at the inner surface of the membrane arm of complex I in close proximity. We propose that the inner surface of the membrane arm represents a workbench for attaching proteins to complex I, which are not directly related to respiratory electron transport, like nucleoside kinases, acyl-carrier proteins or carbonic anhydrases. We speculate that further enzyme activities might be bound to this micro-location in other groups of organisms. © 2017 Scandinavian Plant Physiology Society |
eng |
dc.language.iso |
eng |
eng |
dc.publisher |
Oxford [u.a.] : Wiley-Blackwell |
eng |
dc.relation.ispartofseries |
Physiologia Plantarum 161 (2017), Nr. 1 |
eng |
dc.rights |
Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. |
eng |
dc.subject |
reduced nicotinamide adenine dinucleotide dehydrogenase (ubiquinone) |
eng |
dc.subject |
animal |
eng |
dc.subject |
cell membrane |
eng |
dc.subject |
chemistry |
eng |
dc.subject |
comparative study |
eng |
dc.subject |
metabolism |
eng |
dc.subject |
mitochondrion |
eng |
dc.subject |
molecular model |
eng |
dc.subject |
plant |
eng |
dc.subject |
Animals |
eng |
dc.subject |
Cell Membrane |
eng |
dc.subject |
Electron Transport Complex I |
eng |
dc.subject |
Mitochondria |
eng |
dc.subject |
Models, Molecular |
eng |
dc.subject |
Plants |
eng |
dc.subject.ddc |
580 | Pflanzen (Botanik)
|
|
dc.title |
Structure and function of complex I in animals and plants – a comparative view |
eng |
dc.type |
Article |
eng |
dc.type |
Text |
eng |
dc.relation.essn |
1399-3054 |
eng |
dc.relation.issn |
0031-9317 |
eng |
dc.relation.doi |
https://doi.org/10.1111/ppl.12561 |
eng |
dc.bibliographicCitation.issue |
1 |
|
dc.bibliographicCitation.volume |
161 |
|
dc.bibliographicCitation.firstPage |
6 |
|
dc.bibliographicCitation.lastPage |
15 |
|
dc.description.version |
acceptedVersion |
eng |
tib.accessRights |
frei zug�nglich |
eng |