In vitro studies of maleidride-forming enzymes

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dc.identifier.uri Yin, Sen Friedrich, Steffen Hrupinsa, Vjaceslavs Cox, Russell J. 2021-08-12T11:25:53Z 2021-08-12T11:25:53Z 2021
dc.identifier.citation Yin, S.; Friedrich, S.; Hrupinsa, V.; Cox, R.J.: In vitro studies of maleidride-forming enzymes. In: RSC Advances 11 (2021), Nr. 25, S. 14922-14931. DOI:
dc.description.abstract In vitro assays of enzymes involved in the biosynthesis of maleidrides from polyketides in fungi were performed. The results show that the enzymes are closely related to primary metabolism enzymes of the citric acid cycle in terms of stereochemical preferences, but with an expanded substrate selectivity. A key citrate synthase can react both saturated and unsaturated acyl CoA substrates to give solely anti substituted citrates. This undergoes anti-dehydration to afford an unsaturated precursor which is cyclised in vitro by ketosteroid-isomerase-like enzymes to give byssochlamic acid. eng
dc.language.iso eng
dc.publisher Cambridge : Royal Society of Chemistry
dc.relation.ispartofseries RSC Advances 11 (2021), Nr. 25
dc.rights CC BY-NC 3.0 Unported
dc.subject In vitro eng
dc.subject enzymes eng
dc.subject maleidride-forming enzymes eng
dc.subject polyketides eng
dc.subject fungi eng
dc.subject.ddc 540 | Chemie ger
dc.title In vitro studies of maleidride-forming enzymes
dc.type Article
dc.type Text
dc.relation.essn 2046-2069
dc.bibliographicCitation.issue 25
dc.bibliographicCitation.volume 11
dc.bibliographicCitation.firstPage 14922
dc.bibliographicCitation.lastPage 14931
dc.description.version publishedVersion
tib.accessRights frei zug�nglich

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