dc.identifier.uri |
http://dx.doi.org/10.15488/11185 |
|
dc.identifier.uri |
https://www.repo.uni-hannover.de/handle/123456789/11271 |
|
dc.contributor.author |
Yin, Sen
|
|
dc.contributor.author |
Friedrich, Steffen
|
|
dc.contributor.author |
Hrupinsa, Vjaceslavs
|
|
dc.contributor.author |
Cox, Russell J.
|
|
dc.date.accessioned |
2021-08-12T11:25:53Z |
|
dc.date.available |
2021-08-12T11:25:53Z |
|
dc.date.issued |
2021 |
|
dc.identifier.citation |
Yin, S.; Friedrich, S.; Hrupinsa, V.; Cox, R.J.: In vitro studies of maleidride-forming enzymes. In: RSC Advances 11 (2021), Nr. 25, S. 14922-14931. DOI: https://doi.org/10.1039/D1RA02118D |
|
dc.description.abstract |
In vitro assays of enzymes involved in the biosynthesis of maleidrides from polyketides in fungi were performed. The results show that the enzymes are closely related to primary metabolism enzymes of the citric acid cycle in terms of stereochemical preferences, but with an expanded substrate selectivity. A key citrate synthase can react both saturated and unsaturated acyl CoA substrates to give solely anti substituted citrates. This undergoes anti-dehydration to afford an unsaturated precursor which is cyclised in vitro by ketosteroid-isomerase-like enzymes to give byssochlamic acid. |
eng |
dc.language.iso |
eng |
|
dc.publisher |
Cambridge : Royal Society of Chemistry |
|
dc.relation.ispartofseries |
RSC Advances 11 (2021), Nr. 25 |
|
dc.rights |
CC BY-NC 3.0 Unported |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc/3.0/ |
|
dc.subject |
In vitro |
eng |
dc.subject |
enzymes |
eng |
dc.subject |
maleidride-forming enzymes |
eng |
dc.subject |
polyketides |
eng |
dc.subject |
fungi |
eng |
dc.subject.ddc |
540 | Chemie
|
ger |
dc.title |
In vitro studies of maleidride-forming enzymes |
|
dc.type |
Article |
|
dc.type |
Text |
|
dc.relation.essn |
2046-2069 |
|
dc.relation.doi |
https://doi.org/10.1039/D1RA02118D |
|
dc.bibliographicCitation.issue |
25 |
|
dc.bibliographicCitation.volume |
11 |
|
dc.bibliographicCitation.firstPage |
14922 |
|
dc.bibliographicCitation.lastPage |
14931 |
|
dc.description.version |
publishedVersion |
|
tib.accessRights |
frei zug�nglich |
|