Evidence for enzyme catalysed intramolecular [4+2] Diels-Alder cyclization during the biosynthesis of pyrichalasin H

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dc.identifier.uri http://dx.doi.org/10.15488/10854
dc.identifier.uri https://www.repo.uni-hannover.de/handle/123456789/10936
dc.contributor.author Hantke, Verena
dc.contributor.author Skellam, Elizabeth J.
dc.contributor.author Cox, Russell J.
dc.date.accessioned 2021-05-03T05:28:05Z
dc.date.available 2021-05-03T05:28:05Z
dc.date.issued 2020
dc.identifier.citation Hantke, V.; Skellam, E.J.; Cox, R.J.: Evidence for enzyme catalysed intramolecular [4+2] Diels-Alder cyclization during the biosynthesis of pyrichalasin H. In: Chemical Communications : ChemComm 56 (2020), Nr. 19, S. 2925-2928. DOI: https://doi.org/10.1039/c9cc09590j
dc.description.abstract Cytochalasans are highly complex fungal metabolites which exhibit diverse biological activities. Little is known of the chemical steps involved in the construction of the tricyclic core, which consists of an octahydro-isoindole skeleton fused to a macrocyclic ring. Here, using a directed gene knockout and complementation strategy, we show that PyiF is implicated as the proposed intramolecular [4+2] Diels-Alderase required for construction of the tricyclic core of pyrichalasin H 1. © 2020 The Royal Society of Chemistry. eng
dc.language.iso eng
dc.publisher Cambridge : Soc.
dc.relation.ispartofseries Chemical Communications : ChemComm 56 (2020), Nr. 19
dc.rights CC BY-NC 3.0 Unported
dc.rights.uri https://creativecommons.org/licenses/by-nc/3.0/
dc.subject Cytochalasans eng
dc.subject fungal metabolites eng
dc.subject octahydro-isoindole skeleton eng
dc.subject.ddc 540 | Chemie ger
dc.title Evidence for enzyme catalysed intramolecular [4+2] Diels-Alder cyclization during the biosynthesis of pyrichalasin H
dc.type article
dc.type Text
dc.relation.essn 1364-548X
dc.relation.issn 0009-241X
dc.relation.issn 0022-4936
dc.relation.issn 1359-7345
dc.relation.doi https://doi.org/10.1039/c9cc09590j
dc.bibliographicCitation.issue 19
dc.bibliographicCitation.volume 56
dc.bibliographicCitation.firstPage 2925
dc.bibliographicCitation.lastPage 2928
dc.description.version publishedVersion
tib.accessRights frei zug�nglich


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