dc.identifier.uri |
http://dx.doi.org/10.15488/10854 |
|
dc.identifier.uri |
https://www.repo.uni-hannover.de/handle/123456789/10936 |
|
dc.contributor.author |
Hantke, Verena
|
|
dc.contributor.author |
Skellam, Elizabeth J.
|
|
dc.contributor.author |
Cox, Russell J.
|
|
dc.date.accessioned |
2021-05-03T05:28:05Z |
|
dc.date.available |
2021-05-03T05:28:05Z |
|
dc.date.issued |
2020 |
|
dc.identifier.citation |
Hantke, V.; Skellam, E.J.; Cox, R.J.: Evidence for enzyme catalysed intramolecular [4+2] Diels-Alder cyclization during the biosynthesis of pyrichalasin H. In: Chemical Communications : ChemComm 56 (2020), Nr. 19, S. 2925-2928. DOI: https://doi.org/10.1039/c9cc09590j |
|
dc.description.abstract |
Cytochalasans are highly complex fungal metabolites which exhibit diverse biological activities. Little is known of the chemical steps involved in the construction of the tricyclic core, which consists of an octahydro-isoindole skeleton fused to a macrocyclic ring. Here, using a directed gene knockout and complementation strategy, we show that PyiF is implicated as the proposed intramolecular [4+2] Diels-Alderase required for construction of the tricyclic core of pyrichalasin H 1. © 2020 The Royal Society of Chemistry. |
eng |
dc.language.iso |
eng |
|
dc.publisher |
Cambridge : Soc. |
|
dc.relation.ispartofseries |
Chemical Communications : ChemComm 56 (2020), Nr. 19 |
|
dc.rights |
CC BY-NC 3.0 Unported |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc/3.0/ |
|
dc.subject |
Cytochalasans |
eng |
dc.subject |
fungal metabolites |
eng |
dc.subject |
octahydro-isoindole skeleton |
eng |
dc.subject.ddc |
540 | Chemie
|
ger |
dc.title |
Evidence for enzyme catalysed intramolecular [4+2] Diels-Alder cyclization during the biosynthesis of pyrichalasin H |
|
dc.type |
Article |
|
dc.type |
Text |
|
dc.relation.essn |
1364-548X |
|
dc.relation.issn |
0009-241X |
|
dc.relation.issn |
0022-4936 |
|
dc.relation.issn |
1359-7345 |
|
dc.relation.doi |
https://doi.org/10.1039/c9cc09590j |
|
dc.bibliographicCitation.issue |
19 |
|
dc.bibliographicCitation.volume |
56 |
|
dc.bibliographicCitation.firstPage |
2925 |
|
dc.bibliographicCitation.lastPage |
2928 |
|
dc.description.version |
publishedVersion |
|
tib.accessRights |
frei zug�nglich |
|