Rapid Microfluidic Preparation of Niosomes for Targeted Drug Delivery

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dc.identifier.uri http://dx.doi.org/10.15488/10178
dc.identifier.uri https://www.repo.uni-hannover.de/handle/123456789/10250
dc.contributor.author Ag Seleci, D.
dc.contributor.author Maurer, V.
dc.contributor.author Stahl, Frank
dc.contributor.author Scheper, Thomas
dc.contributor.author Garnweitner, G.
dc.date.accessioned 2020-11-03T09:48:34Z
dc.date.available 2020-11-03T09:48:34Z
dc.date.issued 2019
dc.identifier.citation Ag Seleci, D.; Maurer, V.; Stahl, Frank; Scheper, Thomas; Garnweitner, G.: Rapid Microfluidic Preparation of Niosomes for Targeted Drug Delivery. In: International journal of molecular sciences 20 (2019), Nr. 19, 4696. DOI: https://doi.org/10.3390/ijms20194696
dc.description.abstract Niosomes are non-ionic surfactant-based vesicles with high promise for drug delivery applications. They can be rapidly prepared via microfluidics, allowing their reproducible production without the need of a subsequent size reduction step, by controlled mixing of two miscible phases of an organic (lipids dissolved in alcohol) and an aqueous solution in a microchannel. The control of niosome properties and the implementation of more complex functions, however, thus far are largely unknown for this method. Here we investigate microfluidics-based manufacturing of topotecan (TPT)-loaded polyethylene glycolated niosomes (PEGNIO). The flow rate ratio of the organic and aqueous phases was varied and optimized. Furthermore, the surface of TPT-loaded PEGNIO was modified with a tumor homing and penetrating peptide (tLyp-1). The designed nanoparticular drug delivery system composed of PEGNIO-TPT-tLyp-1 was fabricated for the first time via microfluidics in this study. The physicochemical properties were determined through dynamic light scattering (DLS) and zeta potential analysis. In vitro studies of the obtained formulations were performed on human glioblastoma (U87) cells. The results clearly indicated that tLyp-1-functionalized TPT-loaded niosomes could significantly improve anti-glioma treatment. eng
dc.language.iso eng
dc.publisher Basel : MDPI AG
dc.relation.ispartofseries International journal of molecular sciences 20 (2019), Nr. 19
dc.rights CC BY 4.0 Unported
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject glioma eng
dc.subject microfluidics eng
dc.subject niosomes eng
dc.subject targeted drug delivery eng
dc.subject.ddc 540 | Chemie ger
dc.title Rapid Microfluidic Preparation of Niosomes for Targeted Drug Delivery
dc.type article
dc.type Text
dc.relation.issn 1422-0067
dc.relation.doi https://doi.org/10.3390/ijms20194696
dc.bibliographicCitation.issue 19
dc.bibliographicCitation.volume 20
dc.bibliographicCitation.firstPage 4696
dc.description.version publishedVersion
tib.accessRights frei zug�nglich

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