dc.identifier.uri |
http://dx.doi.org/10.15488/9950 |
|
dc.identifier.uri |
https://www.repo.uni-hannover.de/handle/123456789/10008 |
|
dc.contributor.author |
Walter, Johanna-Gabriela
|
|
dc.contributor.author |
Eilers, Alina
|
|
dc.contributor.author |
Alwis, Lourdes Shanika Malindi
|
|
dc.contributor.author |
Roth, Bernhard Wilhelm
|
|
dc.contributor.author |
Bremer, Kort
|
|
dc.date.accessioned |
2020-08-03T15:49:15Z |
|
dc.date.available |
2020-08-03T15:49:15Z |
|
dc.date.issued |
2020 |
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dc.identifier.citation |
Walter, Johanna-Gabriela; Eilers, Alina; Alwis, Lourdes Shanika Malindi; Roth, Bernhard Wilhelm; Bremer, Kort: SPR Biosensor Based on Polymer Multi-Mode Optical Waveguide and Nanoparticle Signal Enhancement. In: Sensors 20 (2020), Nr. 10, 2889. DOI: https://doi.org/10.3390/s20102889 |
|
dc.description.abstract |
We present a surface plasmon resonance (SPR) biosensor that is based on a planar-optical multi-mode (MM) polymer waveguide structure applied for the detection of biomolecules in the lower nano-molar (nM) range. The basic sensor shows a sensitivity of 608.6 nm/RIU when exposed to refractive index changes with a measurement resolution of 4.3 × 10−3 RIU. By combining the SPR sensor with an aptamer-functionalized, gold-nanoparticle (AuNP)-enhanced sandwich assay, the detection of C-reactive protein (CRP) in a buffer solution was achieved with a response of 0.118 nm/nM. Due to the multi-mode polymer waveguide structure and the simple concept, the reported biosensor is well suited for low-cost disposable lab-on-a-chip applications and can be used with rather simple and economic devices. In particular, the sensor offers the potential for fast and multiplexed detection of several biomarkers on a single integrated platform. |
eng |
dc.language.iso |
eng |
|
dc.publisher |
Basel : MDPI |
|
dc.relation.ispartofseries |
Sensors 20 (2020), Nr. 10 |
|
dc.rights |
CC BY 4.0 Unported |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
surface plasmon resonance (SPR) |
eng |
dc.subject |
sensor |
eng |
dc.subject |
planar-optical |
eng |
dc.subject |
multi-mode |
eng |
dc.subject |
waveguide |
eng |
dc.subject |
biosensor |
eng |
dc.subject |
aptamer |
eng |
dc.subject |
gold-nanoparticle |
eng |
dc.subject |
lab-on-a-chip |
eng |
dc.subject.ddc |
620 | Ingenieurwissenschaften und Maschinenbau
|
ger |
dc.title |
SPR Biosensor Based on Polymer Multi-Mode Optical Waveguide and Nanoparticle Signal Enhancement |
eng |
dc.type |
Article |
|
dc.type |
Text |
|
dc.relation.doi |
https://doi.org/10.3390/s20102889 |
|
dc.bibliographicCitation.issue |
10 |
|
dc.bibliographicCitation.volume |
20 |
|
dc.bibliographicCitation.firstPage |
2889 |
|
dc.description.version |
publishedVersion |
|
tib.accessRights |
frei zug�nglich |
|